ArticleBiophysical journal2012
Phase transitions in coarse-grained lipid bilayers containing cholesterol by molecular dynamics simulations.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Development of Transferable Coarse-Grained Lipid Models with Optimized Structural and Elastic Membrane Properties.Journal of chemical theory and computation · 2025Article
- Gadolinium Effects on Liposome Fluidity and Size Depend on the Headgroup and Side Chain Structure of Key Mammalian Brain Lipids.Molecules (Basel, Switzerland) · 2023Article
- Emerging Diamond Quantum Sensing in Bio-Membranes.Membranes · 2022Review
- The Two Faces of the Liquid Ordered Phase.The journal of physical chemistry letters · 2022Article
- Role of cholesterol flip-flop in oxidized lipid bilayers.Biophysical journal · 2021Article
- Martini Coarse-Grained Model of Hyaluronic Acid for the Structural Change of Its Gel in the Presence of Monovalent and Divalent Salts.International journal of molecular sciences · 2020Article
- Spontaneous Curvature, Differential Stress, and Bending Modulus of Asymmetric Lipid Membranes.Biophysical journal · 2020Article
- Area Compressibility Moduli of the Monolayer Leaflets of Asymmetric Bilayers from Simulations.Biophysical journal · 2019Article
- Antimicrobial peptide ROAD-1 triggers phase change in local membrane environment to execute its activity.Journal of molecular modeling · 2019Article
- Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.Chemical reviews · 2019Article
- Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics.Journal of computer-aided molecular design · 2018Article
- Molecular Structuring and Phase Transition of Lipid-Based Formulations upon Water Dispersion: A Coarse-Grained Molecular Dynamics Simulation Approach.Molecular pharmaceutics · 2017Article
- Nanoscale Membrane Domain Formation Driven by Cholesterol.Scientific reports · 2017Article
- Hysteresis and the Cholesterol Dependent Phase Transition in Binary Lipid Mixtures with the Martini Model.The journal of physical chemistry. B · 2016Article
- Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants.NPG Asia materials · 2015Article
- Membrane-mediated regulation of the intrinsically disordered CD3ϵ cytoplasmic tail of the TCR.Biophysical journal · 2015Article
- Membrane partitioning of anionic, ligand-coated nanoparticles is accompanied by ligand snorkeling, local disordering, and cholesterol depletion.PLoS computational biology · 2014Article
- LipidWrapper: an algorithm for generating large-scale membrane models of arbitrary geometry.PLoS computational biology · 2014Article
- The molecular structure of the liquid-ordered phase of lipid bilayers.Journal of the American Chemical Society · 2014Article
- Simulation study of the structure and phase behavior of ceramide bilayers and the role of lipid head group chemistry.Journal of chemical theory and computation · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coarse-grained simulations of model membranes containing mixtures of phospholipid and cholesterol molecules at different concentrations and temperatures have been performed. A random mixing without tendencies for segregation or formation of domains was observed on spatial scales corresponding to a few thousand lipids and timescales up to several microseconds. The gel-to-liquid crystalline phase transition is successively weakened with increasing amounts of cholesterol without disappearing completely even at a concentration of cholesterol as high as 60%. The phase transition temperature increases slightly depending on the cholesterol concentration. The gel phase system undergoes a transition with increasing amounts of cholesterol from a solid-ordered phase into a liquid-ordered one. In the solid phase, the amplitude of the oscillations in the radial distribution function decays algebraically with a prefactor that goes to zero at the solid-liquid transition.
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