ArticleThe Journal of allergy and clinical immunology2013
Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2020Pooled it
- Trial
- Global burden of asthma among children and adolescents with projections to 2050: a comprehensive review and forecasted modeling study.Clinical and experimental pediatrics · 2025Article
- Utility of biomarkers in the diagnosis and monitoring of asthmatic children.The World Allergy Organization journal · 2023Review
- Impulse Oscillometry System for the Diagnosis of Wheezing Episode in Children in Office Practice.Journal of asthma and allergy · 2022Article
- A Current Perspective of Allergic Asthma: From Mechanisms to Management.Handbook of experimental pharmacology · 2022Review
- Article
- Evolution of Airway Inflammation in Preschoolers with Asthma-Results of a Two-Year Longitudinal Study.Journal of clinical medicine · 2020Article
- Virus-Induced Asthma/Wheeze in Preschool Children: Longitudinal Assessment of Airflow Limitation Using Impulse Oscillometry.Journal of clinical medicine · 2019Article
- Effect of PD-1 inhibitor on exhaled nitric oxide and pulmonary function in non-small cell lung cancer patients with and without COPD.International journal of chronic obstructive pulmonary disease · 2019Article
- Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children.International journal of environmental research and public health · 2016Article
- Rhinovirus infection in young children is associated with elevated airway TSLP levels.The European respiratory journal · 2014Article
- Advances in pediatric asthma in 2013: coordinating asthma care.The Journal of allergy and clinical immunology · 2014Article
- Exhaled nitric oxide is related to atopy, but not asthma in adolescents with bronchiolitis in infancy.BMC pulmonary medicine · 2013Article
- Infection-related asthma.The journal of allergy and clinical immunology. In practiceReview
- Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma.The journal of allergy and clinical immunology. In practiceReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is disputed whether recurrent episodes of wheeze in preschool-aged children comprise a distinct asthma phenotype.
objectiveWe sought to prospectively assess airflow limitation and airway inflammation in children 4 to 6 years old with episodic virus-induced wheeze.
methodsNinety-three children 4 to 6 years old with a history of mild, virus-induced episodes of wheeze who were able to perform acceptable fraction of exhaled nitric oxide (Feno) maneuvers and spirometry (with forced expiratory time ≥0.5 seconds) were followed prospectively. Lung function and Feno values were measured every 6 weeks (baseline) within the first 48 hours of an acute wheezing episode (day 0) and 10 and 30 days later. Symptom scores and peak flow measurement were recorded daily.
resultsForty-three children experienced a wheezing episode. At day 0, Feno values were significantly increased, whereas forced expiratory volume at 0.5 seconds (FEV(0.5)) significantly decreased compared with baseline (16 ppb [interquartile range {IQR}, 13-20 ppb] vs 9 ppb IQR, 7-11 ppb] and 0.84 L [IQR, 0.75-0.99 L] vs 0.99 L [IQR, 0.9-1.07 L], respectively; both P < .001). Airflow limitation at day 0 was reversible after bronchodilation. FEV(0.5) and Feno values were significantly associated with each other and with lower and upper respiratory tract symptoms when assessed longitudinally but not cross-sectionally at all time points independently of atopy. Feno and FEV(0.5) values returned to baseline levels within 10 days.
conclusionsMild episodes of wheeze in preschoolers are characterized by enhanced airway inflammation, reversible airflow limitation, and asthma-related symptoms. Feno values increase significantly during the first 48 hours and return to personal baseline within 10 days from the initiation of the episode. Longitudinal follow-up suggests that symptoms, inflammation, and lung function correlate well in this phenotype of asthma.
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