ReviewXenobiotica; the fate of foreign compounds in biological systems2013
Assessment of immunotoxicity using precision-cut tissue slices.
Review in Xenobiotica; the fate of foreign compounds in biological systems, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Utility of in Vivo and Ex-vivo Models in Food Allergy Research: Lessons for Shrimp Allergy.Clinical reviews in allergy & immunology · 2025Review
- Applying new approach methodologies to assess next-generation tobacco and nicotine products.Frontiers in toxicology · 2024Review
- Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.MedComm · 2023Review
- Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for "on-demand" use and long-term cultures.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Drug Repurposing by Tumor Tissue Editing.Frontiers in oncology · 2022Review
- A modified protocol for successful miRNA profiling in human precision-cut lung slices (PCLS).BMC research notes · 2021Article
- Novel Methods and Approaches for Safety Evaluation of Nanoparticle Formulations: A Focus TowardsFrontiers in pharmacology · 2021Review
- Chemical warfare agent research in precision-cut tissue slices-a useful alternative approach.Annals of the New York Academy of Sciences · 2020Review
- Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion.Infection and immunity · 2019Article
- HumanAsia Pacific allergy · 2019Review
- Pathway-based predictive approaches for non-animal assessment of acute inhalation toxicity.Toxicology in vitro : an international journal published in association with BIBRA · 2018Review
- Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices.Journal of visualized experiments : JoVE · 2018Article
- Human Pulmonary 3D Models For Translational Research.Biotechnology journal · 2018Review
- RNA isolation from precision-cut lung slices (PCLS) from different species.BMC research notes · 2017Article
- Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality.Journal of occupational medicine and toxicology (London, England) · 2017Article
- Use of nonhuman primates in obstructive lung disease research - is it required?Primate biology · 2017Review
- Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices.Particle and fibre toxicology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1.When the immune system encounters incoming infectious agents, this generally leads to immunity. The evoked immune response is usually robust, but can be severely perturbed by potentially harmful environmental agents such as chemicals, pharmaceuticals and allergens. 2.Immunosuppression, hypersensitivity and autoimmunity may occur due to changed immune activity. Evaluation of the immunotoxic potency of agents as part of risk assessment is currently established in vivo with animal models and in vitro with cell lines or primary cells. 3.Although in vivo testing is usually the most relevant situation for many agents, more and more in vitro models are being developed for assessment of immunotoxicity. In this context, hypersensitivity and immunosuppression are considered to be a primary focus for developing in vitro methods. Three-dimensional organotypic tissue models are also part of current research in immunotoxicology. 4.In recent years, there has been a revival of interest in organotypic tissue models. In the context of immunotoxicity testing, precision-cut lung slices in particular have been intensively studied. Therefore, this review is very much focused on pulmonary immunotoxicology. Respiratory hypersensitivity and inflammation are further highlighted aspects of this review. Immunotoxicity assessment currently is of limited use in other tissue models, which are therefore described only briefly within this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.