ArticleClinical and experimental immunology2013
T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto's thyroiditis.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- The causal relationship between diabetes mellitus and hashimoto thyroiditis: A two-sample mendelian randomization analysis.Medicine · 2026Article
- Autoimmune Processes and Chronic Inflammation as Independent Risk Factors for Metabolic Complications in Women with Polycystic Ovary Syndrome.Metabolites · 2025Article
- Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway.Annals of medicine · 2024Article
- Effects of iodine intake on gut microbiota and gut metabolites in Hashimoto thyroiditis-diseased humans and mice.Communications biology · 2024Article
- Initial BMI effects on clinical presentation and prognosis in neuromyelitis optica spectrum disorder.Annals of clinical and translational neurology · 2023Article
- Hypothyroidism induced by immune checkpoint inhibitors combined with antiangiogenic agents is associated with higher body mass index.Journal of thoracic disease · 2023Article
- High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche.Frontiers in pediatrics · 2023Article
- Comprehensive immunophenotypic analysis reveals the pathological involvement of Th17 cells in Graves' disease.Scientific reports · 2022Article
- Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer.Biomolecules · 2022Review
- Leptin receptor antagonist attenuates experimental autoimmune thyroiditis in mice by regulating Treg/Th17 cell differentiation.Frontiers in endocrinology · 2022Article
- The Role of Leptin in the Association between Obesity and Psoriasis.Biomolecules & therapeutics · 2021Review
- Autoantibody Production in Obesity: Is There Evidence for a Link Between Obesity and Autoimmunity?Current obesity reports · 2020Review
- The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction.International journal of endocrinology · 2020Review
- Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress.Frontiers in immunology · 2019Review
- Changes in Nutritional Status Impact Immune Cell Metabolism and Function.Frontiers in immunology · 2018Review
- Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases.Thyroid research · 2018Article
- Obesity, Fat Mass and Immune System: Role for Leptin.Frontiers in physiology · 2018Review
- Relationship between leptin concentration and body fat with peripheral blood mononuclear cells cytokines among obese and overweight adults.Irish journal of medical science · 2017Article
- IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Review
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin modulates T cell function and plays an important role in autoimmune diseases. Our study aimed to explore the role of leptin and T helper type 17 (Th17) cells in Hashimoto's thyroiditis patients. Twenty-seven patients with Hashimoto's thyroiditis (HT) and 20 healthy controls were enrolled into the current study. A modest increase of plasma leptin in HT patients and the CD4(+) T cell-derived leptin from HT patients was stronger than that from healthy controls. In HT patients, there are no statistically significant correlations between plasma leptin concentrations and the percentage of Th17 cells or the level of retinoic acid-related orphan receptor γt (RORγt), but strong positive correlations were observed between CD4(+) T cell-derived leptin and the percentage of Th17 cells or the level of RORγt mRNA, and additionally significantly up-regulated leptin, interleukin (IL)17 and RORγt mRNA levels in the thyroid tissue. Furthermore, neutralization of leptin decreases the frequency of Th17 cells in vitro. Current study has revealed an increased leptin involvment in Hashimoto's thyroiditis associated with an increased number of Th17 cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.