ReviewJournal of toxicology and environmental health. Part B, Critical reviews2012
Respiratory health effects of large animal farming environments.
Review in Journal of toxicology and environmental health. Part B, Critical reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Reporting of structural population assumptions in prevalence-based studies of animal feeding operations and community health.Frontiers in public health · 2026Pooled it
- Exposures and health outcomes in relation to bioaerosol emissions from composting facilities: a systematic review of occupational and community studies.Journal of toxicology and environmental health. Part B, Critical reviews · 2015Pooled it
- Exploratory Room-Level Acoustic Soundscape Monitoring of Cough-like Events Under Standard and Ventilation-Restricted Pig-Housing Conditions Using Audio Spectrogram Transformer.Animals : an open access journal from MDPI · 2026Article
- A novel two-hit murine model of inhaled occupational exposure-induced lung disease.Physiological reports · 2026Article
- Microbial Aerosols in Livestock Farming Environment: A Threat That Cannot Be Ignored.Veterinary sciences · 2025Review
- Animal farming and the oral microbiome in the Agricultural Health Study.Environmental research · 2025Article
- Probiotic supplementation regulated swine growth performance, fecal odor reduction and carcass characteristics by modulating intestinal microbiome.Animal microbiome · 2025Article
- Medium-expansion water-based foam depopulation of sheep and goats.Scientific reports · 2025Article
- Article
- Lung-delivered IL-10 therapy elicits beneficial effects via immune modulation in organic dust exposure-induced lung inflammation.Journal of immunotoxicology · 2024Article
- A Systematized Overview of Published Reviews on Biological Hazards, Occupational Health, and Safety.Safety and health at work · 2023Review
- Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA).International journal of molecular sciences · 2023Article
- Divergent TLR2 and TLR4 Activation by Fungal Spores and Species Diversity in Dust from Waste Sorting Plants.Applied and environmental microbiology · 2023Article
- The association of chronic bronchitis and airflow obstruction with lifetime and current farm activities in a sample of rural adults in Iowa.International archives of occupational and environmental health · 2022Article
- IL-22 regulates inflammatory responses to agricultural dust-induced airway inflammation.Toxicology and applied pharmacology · 2022Article
- Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction.Cell and tissue research · 2022Article
- Child Labor in Family Tobacco Farms in Southern Brazil: Occupational Exposure and Related Health Problems.International journal of environmental research and public health · 2021Article
- Challenges in Diagnosing Occupational Chronic Obstructive Pulmonary Disease.Medicina (Kaunas, Lithuania) · 2021Review
- Organic dust exposure induces stress response and mitochondrial dysfunction in monocytic cells.Histochemistry and cell biology · 2021Article
- Association of Agricultural, Occupational, and Military Inhalants With Autoantibodies and Disease Features in US Veterans With Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
With increases in large animal-feeding operations to meet consumer demand, adverse upper and lower respiratory health effects in exposed agriculture workers are a concern. The aim of this study was to review large animal confinement feeding operational exposures associated with respiratory disease with a focus on recent advances in the knowledge of causative factors and cellular and immunological mechanisms. A PubMed search was conducted with the keywords airway, farm, swine, dairy, horse, cattle inflammation, organic dust, endotoxin, and peptidoglycan, among items were published between 1980 and now. Articles were selected based on their relevance to environmental exposure and reference to airway diseases. Airway diseases included rhinitis, sinusitis, mucus membrane inflammation syndrome, asthma, chronic bronchitis, chronic obstructive pulmonary disease, hypersensitivity pneumonitis, and organic dust toxic syndrome. There is lower prevalence of immunoglobulin (Ig) E-mediated asthma and atopy in farmers and their children, but organic dust worsens existing asthma. Multiple etiologic factors are linked to disease, including allergens, organic dusts, endotoxins, peptidoglycans, and gases. Large animal confinement feeding operations contain a wide diversity of microbes with increasing focus on gram-positive bacteria and archaebacteria as opposed to gram-negative bacteria in mediating disease. Toll-like receptors (TLR) and nucleotide oligomerization domain (NOD)-like innate immune pathways respond to these exposures. Finally, a chronic inflammatory adaptation, tolerance-like response in chronically exposed workers occurs. Large animal confinement farming exposures produce a wide spectrum of upper and lower respiratory tract diseases due to the complex diversity of organic dust, particulates, microbial cell wall components, and gases and resultant activation of various innate immune receptor signaling pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.