Evidence map›Paper›PMID 23199200›Full record

ReviewExpert opinion on drug delivery2013

Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.

Hyejung Mok, Miqin Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Expert opinion on drug delivery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Fast Colorimetric Detection of HInternational journal of molecular sciences · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hyejung MokKonkuk University, Department of Bioscience and Biotechnology, Seoul 143-701, Republic of Korea.
Miqin Zhang

Funding

Multifuctional Nanovector For Diagnosis And Treatment Of Pediatric Brain CancerR01EB006043 · NIBIB · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2007 to 2010
$1.6M
Nanovectors For Brain Tumor Diagnosis And TreatmentR01CA134213 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2007 to 2011
$1.5M
NCI NIH HHS R01 CA134213NCI NIH HHS R01CA134213NIBIB NIH HHS R01 EB006043NIBIB NIH HHS R01EB006043
6 · The paper itself

Abstract

introductionSuperparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedical applications. In particular, magnetically driven carriers are drawing considerable interest as an emerging therapeutic delivery system because of their superior delivery efficiency. AREAS COVERED: This article reviews the recent advances in use of SPION-based carrier systems to improve the delivery efficiency and target specificity of biotherapeutics. The authors examine various formulations of SPION-based delivery systems, including SPION micelles, clusters, hydrogels, liposomes and micro/nanospheres, as well as their specific applications in delivery of biotherapeutics. EXPERT OPINION: Recently, biotherapeutics including therapeutic cells, proteins and genes have been studied as alternative treatments to various diseases. Despite the advantages of high target specificity and low adverse effects, clinical translation of biotherapeutics has been hindered by the poor stability and low delivery efficiency compared with chemical drugs. Accordingly, biotherapeutic delivery systems that can overcome these limitations are actively pursued. SPION-based materials can be ideal candidates for developing such delivery systems because of their excellent biocompatibility and superparamagnetism that enables long-term accumulation/retention at target sites by utilization of a suitable magnet. In addition, synthesis technologies for production of finely tuned, homogeneous SPIONs have been well developed, which may promise their rapid clinical translation.

Indexed as

Drug CarriersAnimalsBiocompatible MaterialsBiological TherapyChemistry, PharmaceuticalFerric CompoundsHumansLipidsLiposomesMagnetic FieldsMicellesNanoparticlesPharmaceutical PreparationsBiocompatible MaterialsDrug CarriersFerric Compoundsferric oxideLipidsLiposomesMicellesPharmaceutical Preparations

Identifiers

PMID23199200
PMCPMC4167583

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.