ReviewMalaria journal2012
Malaria in infants aged less than six months - is it an area of unmet medical need?
Review in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Epidemiology of clinical congenital and neonatal malaria in endemic settings: a systematic review and meta-analysis.Malaria journal · 2020Pooled it
- Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children.Nature communications · 2021Trial
- Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®).Malaria journal · 2015Trial
- Malaria Incidence, Growth, and their Relationship among a Cohort of Malawian Children.The American journal of tropical medicine and hygiene · 2026Article
- Natural History and the Burden of Malaria During the First Year of Life in the High-Transmission Setting of Uganda.The American journal of tropical medicine and hygiene · 2026Article
- Malaria in children aged <6 months: a narrative review of current evidence, recommendations and practice gaps.Tropical medicine and health · 2026Review
- Assessing the impact of climate and control interventions on spatio-temporal malaria dynamics using a stochastic metapopulation model.PLoS computational biology · 2026Article
- Comparison of verbal autopsy using a large language model to biologically confirmed causes of death for malaria and other communicable diseases among children in six sub-Saharan African countries.Malaria journal · 2026Article
- Pharmacokinetics, safety and efficacy of an optimized dose of artemether-lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA).Tropical medicine and health · 2025Article
- Article
- Use of population pharmacokinetic-pharmacodynamic modelling to inform antimalarial dose optimization in infants.British journal of clinical pharmacology · 2025Review
- Prevalance and risk factors of congenital malaria in Osogbo, Southwestern Nigeria.German medical science : GMS e-journal · 2025Article
- Congenital Plasmodium vivax in a 3-day-old neonate: a case report.Journal of medical case reports · 2024Article
- Prevalence and factors associated with cerebral malaria among children aged 6 to 59 months with severe malaria in Western Uganda: a hospital-based cross-sectional study.BMC pediatrics · 2024Article
- Forecasting malaria dynamics based on causal relations between control interventions, climatic factors, and disease incidence in western Kenya.Journal of global health · 2024Article
- Burden of child mortality from malaria in high endemic areas: Results from the CHAMPS network using minimally invasive tissue sampling.The Journal of infection · 2024Article
- Unravelling factors associated with malaria parasitaemia among children 6-24 months to inform malaria interventions in Nigeria: evidence from 2021 Malaria Indicator Survey.Malaria journal · 2023Article
- Malaria in newborn: A missed entity for primary care physician.Journal of family medicine and primary care · 2023Review
- Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood.Malaria journal · 2023Article
- Malaria, climate variability, and interventions: modelling transmission dynamics.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 7 countries.
Funding
Abstract
Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.