ArticleAnalytical chemistry2013
Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis.
Article in Analytical chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.
- Imaging and quantifying drug delivery in skin - Part 2: Fluorescence andvibrational spectroscopic imaging methods.Advanced drug delivery reviews · 2020Pooled it
- Label-free quantification of topical drug permeation in skin using sparse spectral sampling stimulated Raman scattering imaging.Biophotonics discovery · 2026Article
- Real-time photoactivated SRS imaging enables spatiotemporally controlled nitroxyl release and therapeutic guidance in vivo.Nature communications · 2026Article
- Stimulated Raman photothermal microscopy: theory and implementation.Advances in optics and photonics · 2026Article
- Simultaneous dual-Raman-shift scanning-free stimulated Raman scattering microscopy for label-free biomolecular imaging.Nature communications · 2026Article
- Effects of biological fixation methods on stimulated Raman scattering microscopy signal.bioRxiv : the preprint server for biology · 2025Article
- Artificial Intelligence-Powered Raman Spectroscopy through Open Science and FAIR Principles.ACS nano · 2025Review
- Single-Molecule Vibrational Thermometry.The journal of physical chemistry. B · 2025Article
- Self-Supervised Elimination of Non-Independent Noise in Hyperspectral Imaging.Newton ((New York, N.Y.) · 2025Article
- High-Specificity Spatiotemporal Cholesterol Detection by Quadrature Phase-Shifted Polarization Stimulated Raman Imaging.Angewandte Chemie (International ed. in English) · 2025Article
- Photon-counting Raman spectroscopy at a MHz spectral rate for biochemical imaging of an entire organism.Nature communications · 2025Article
- Machine learning empowered coherent Raman imaging and analysis for biomedical applications.Communications engineering · 2025Review
- Imaging Metabolic Flow of Water in Plants with Isotope-Traced Stimulated Raman Scattering Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Molecular Fingerprinting of Mouse Brain Using Ultrabroadband Coherent Anti-Stokes Raman Scattering (CARS) Microspectroscopy Empowered by Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS).Chemical & biomedical imaging · 2024Article
- Label-Free Screening of Drug-Induced Liver Injury Using Stimulated Raman Scattering Microscopy and Spectral Phasor Analysis.Analytical chemistry · 2024Article
- Frequency-Domain Low-Wavenumber Hyperspectral Stimulated Raman Scattering Microscopy.Analytical chemistry · 2024Article
- Programmable hyperspectral coherent anti-Stokes Raman scattering microscopy.Optics letters · 2024Article
- Perspectives on SRS Imaging of Nanoparticles.Accounts of materials research · 2023Article
- Coherent Raman scattering microscopy of lipid droplets in cells and tissues.Journal of Raman spectroscopy : JRS · 2023Article
- Profiling single cancer cell metabolism via high-content SRS imaging with chemical sparsity.Science advances · 2023Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Spectroscopic imaging has been an increasingly critical approach for unveiling specific molecules in biological environments. Toward this goal, we demonstrate hyperspectral stimulated Raman loss (SRL) imaging by intrapulse spectral scanning through a femtosecond pulse shaper. The hyperspectral stack of SRL images is further analyzed by a multivariate curve resolution (MCR) method to reconstruct quantitative concentration images for each individual component and retrieve the corresponding vibrational Raman spectra. Using these methods, we demonstrate quantitative mapping of dimethyl sulfoxide concentration in aqueous solutions and in fat tissue. Moreover, MCR is performed on SRL images of breast cancer cells to generate maps of principal chemical components along with their respective vibrational spectra. These results show the great capability and potential of hyperspectral SRL microscopy for quantitative imaging of complicated biomolecule mixtures through resolving overlapped Raman bands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.