ArticleJournal of medical primatology2013
Pleuro-pulmonary endometriosis in baboons (Papio spp.): insights into pathogenesis.
Article in Journal of medical primatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Known, the Unknown and the Future of the Pathophysiology of Endometriosis.International journal of molecular sciences · 2024Review
- A protocol for creating endometriosis in rhesus macaques (Macaca mulatta).Journal of medical primatology · 2023Article
- Histological and Immunohistochemical Characterization of a Case of Endometriosis in a Guinea PigCase reports in veterinary medicine · 2017Article
- Mortality in captive baboons (Papio spp.): a-23-year study.Journal of medical primatology · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundHuman pleuro-pulmonary endometriosis (PPE) is rare. Recently, we identified several cases of abdominal endometriosis in baboons that developed PPE. MATERIALS AND
methodsTen cases of PPE and four of intra-abdominal endometriosis (three simultaneous) were identified at necropsy in baboons (Papio spp.) found dead due to natural causes. The endometriotic lesions were evaluated using immunohistochemistry.
resultsThe stromal (CD10+) and epithelial cells in intra-abdominal cases were estrogen and progesterone receptor (ER/PR) positive and thyroid transcription factor 1 (TTF-1) negative similar to that seen in humans. In contrast, the PPE cases displayed TTF-1-positive epithelium lining the cystic spaces, while the stroma was ER/PR positive similar to that in abdominal endometriosis. Both lymph nodes and spindle cell rests in lung interstitium contained ER/PR-positive stromal cells.
conclusionsThe lung lesions were different from the abdominal lesions in having a TTF-1-positive lining epithelium. The deep pulmonary interstitial and lymph node endometrial stromal rests probably arrive via lymphatic route. The endometrial stroma is the driving force in PPE upon which the lung-specific epithelium condenses and may require a novel approach to therapy.
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