ArticleCardiology research and practice2012
Bicuspid aortic valve disease and ascending aortic aneurysms: gaps in knowledge.
Article in Cardiology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?Oxidative medicine and cellular longevity · 2018Trial
- From maturation to degeneration: Distinct biological trajectories in bicuspid and tricuspid aortopathy.Experimental physiology · 2026Review
- Evaluation of bicuspid aortic valve-associated aortopathic changes using third-generation dual-source computed tomography.World journal of radiology · 2026Article
- Aortopathy in Bicuspid Aortic Valve: Pathophysiology, Risk Stratification and Surgical Decision-Making-A Narrative Review.Journal of clinical medicine · 2026Review
- Trends in Bicuspid Aortic Valve-Attributable Death in the United States From 2010 to 2020.Journal of the American Heart Association · 2025Article
- The Role of Cardiovascular Magnetic Resonance Imaging in Athletic Individuals-A Narrative Review.Journal of clinical medicine · 2025Review
- Non-Trileaflet Aortic Valve Aortopathies.Life (Basel, Switzerland) · 2025Review
- Observational
- The hidden unicuspid: Recurring aortic stenosis post-valvuloplasty from a unicuspid aortic valve masquerading as bicuspid.Journal of cardiology cases · 2023Article
- Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies.Cellular and molecular life sciences : CMLS · 2023Article
- The Complex Relationship between Hypoxia Signaling, Mitochondrial Dysfunction and Inflammation in Calcific Aortic Valve Disease: Insights from the Molecular Mechanisms to Therapeutic Approaches.International journal of molecular sciences · 2023Review
- Cardiovascular Diseases and Zinc.Biological trace element research · 2023Review
- Risk Factors for Aortic Dissection.US cardiology · 2023Review
- Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases?Journal of clinical medicine · 2022Article
- Validating In Silico and In Vitro Patient-Specific Structural and Flow Models with Transcatheter Bicuspid Aortic Valve Replacement Procedure.Cardiovascular engineering and technology · 2022Article
- Article
- Controlled Comparison of Simulated Hemodynamics Across Tricuspid and Bicuspid Aortic Valves.Annals of biomedical engineering · 2022Article
- Assessment of Paravalvular Leak Severity and Thrombogenic Potential in Transcatheter Bicuspid Aortic Valve Replacements Using Patient-Specific Computational Modeling.Journal of cardiovascular translational research · 2022Article
- Surgery for endocarditis in patients with bicuspid aortic valves.Annals of cardiothoracic surgery · 2022Article
- The Relationship between Arterial Elasticity Parameters of Ascending Aorta, Abdominal Aorta and Carotid Arteries with Carotid Intima Media Thickness in Children with Bicuspid Aortic Valve.Anatolian journal of cardiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bicuspid aortic valve is the most common congenital cardiac anomaly in developed nations. The abnormal bicuspid morphology of the aortic valve results in valvular dysfunction and subsequent hemodynamic derangements. However, the clinical presentation of bicuspid aortic valve disease remains quite heterogeneous with patients presenting from infancy to late adulthood with variable degrees of valvular stenosis and insufficiency and associated abnormalities including aortic coarctation, hypoplastic left heart structures, and ascending aortic dilatation. Emerging evidence suggests that the heterogeneous presentation of bicuspid aortic valve phenotypes may be a more complex matter related to congenital, genetic, and/or connective tissue abnormalities. Optimal management of patients with BAV disease and associated ascending aortic aneurysms often requires a thoughtful approach, carefully assessing various risk factors of the aortic valve and the aorta and discerning individual indications for ongoing surveillance, medical management, and operative intervention. We review current concepts of anatomic classification, pathophysiology, natural history, and clinical management of bicuspid aortic valve disease with associated ascending aortic aneurysms.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.