ArticleJournal of global health2011
Emerging biomarkers for the diagnosis of severe neonatal infections applicable to low resource settings.
Article in Journal of global health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Viral etiology of hospitalized acute lower respiratory infections in children under 5 years of age -- a systematic review and meta-analysis.Croatian medical journal · 2013Pooled it
- The association between mannose binding lectin gene polymorphisms and the risk of neonatal sepsis: an updated meta-analysis.Heliyon · 2023Review
- Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa.Scientific reports · 2022Article
- Investigation of salivary C-reactive protein and interleukin-18 for the diagnosis of neonatal sepsis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021Article
- Predictive model for bacterial late-onset neonatal sepsis in a tertiary care hospital in Thailand.BMC infectious diseases · 2020Article
- Multiplexed Remote SPR Detection of Biological Interactions through Optical Fiber Bundles.Sensors (Basel, Switzerland) · 2020Article
- Heterogeneous Immunoassay Using Channels and Droplets in a Digital Microfluidic Platform.Micromachines · 2019Article
- Use of Mannose-Binding Lectin Gene Polymorphisms and the Serum MBL Level for the Early Detection of Neonatal Sepsis.Journal of pediatric genetics · 2018Article
- Cardiorespiratory control and cytokine profile in response to heat stress, hypoxia, and lipopolysaccharide (LPS) exposure during early neonatal period.Physiological reports · 2016Article
- Future of biobanks - bigger, longer, and more dimensional.Croatian medical journal · 2013Article
- The role of mannose-binding lectin in severe sepsis and septic shock.Mediators of inflammation · 2013Review
- Reducing the burden of maternal and neonatal infections in low income settings.Journal of global health · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
More than 500 000 children die each year in low resource settings due to serious neonatal infections. Better diagnostics that can be utilized in these settings to identify infected infants have the potential to significantly reduce neonatal deaths and the associated morbidity. A systematic review was performed and identified more than 250 potential new biomarkers for the diagnosis of serious neonatal infections. Eight of these biomarkers were both high-performance and high-abundance (antithrombin, inter-α inhibitor proteins, interferon-γ inducible protein-10, interleukin-1 receptor antagonist, LPS binding protein, mannose binding lectin, serum amyloid A, resistin, visfatin), and are promising for the diagnosis of serious neonatal infections in low resource settings. Future clinical trials comparing these biomarkers with more traditional biomarkers seem warranted.
Identifiers
23198120PMC3484779What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.