ArticleInternational journal of biomedical imaging2012
Ex vivo fluorescence molecular tomography of the spine.
Article in International journal of biomedical imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Noninvasive multimodal fluorescence and magnetic resonance imaging of whole-organ intervertebral discs.Biomedical optics express · 2021Article
- Hyperspectral wide-field time domain single-pixel diffuse optical tomography platform.Biomedical optics express · 2018Article
- Direct approach to compute Jacobians for diffuse optical tomography using perturbation Monte Carlo-based photon "replay".Biomedical optics express · 2018Article
- Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018Review
- Generalized mesh-based Monte Carlo for wide-field illumination and detection via mesh retessellation.Biomedical optics express · 2016Article
- Mesh Optimization for Monte Carlo-Based Optical Tomography.Photonics · 2015Article
- Nanoparticle labeling of bone marrow-derived rat mesenchymal stem cells: their use in differentiation and tracking.BioMed research international · 2015Article
- Reduced temporal sampling effect on accuracy of time-domain fluorescence lifetime Förster resonance energy transfer.Journal of biomedical optics · 2014Article
- L(p) regularization for early gate fluorescence molecular tomography.Optics letters · 2014Article
- Spatial light modulator based active wide-field illumination for ex vivo and in vivo quantitative NIR FRET imaging.Biomedical optics express · 2014Article
- Adaptive wide-field optical tomography.Journal of biomedical optics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the potential of fluorescence molecular tomography to image ex vivo samples collected from a large animal model, in this case, a dog spine. Wide-field time-gated fluorescence tomography was employed to assess the impact of multiview acquisition, data type, and intrinsic optical properties on the localization and quantification accuracy in imaging a fluorescent inclusion in the intervertebral disk. As expected, the TG data sets, when combining early and late gates, provide significantly better performances than the CW data sets in terms of localization and quantification. Moreover, the use of multiview imaging protocols led to more accurate localization. Additionally, the incorporation of the heterogeneous nature of the tissue in the model to compute the Jacobians led to improved imaging performances. This preliminary imaging study provides a proof of concept of the feasibility of quantitatively imaging complex ex vivo samples nondestructively and with short acquisition times. This work is the first step towards employing optical molecular imaging of the spine to detect and characterize disc degeneration based on targeted fluorescent probes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.