Evidence map›Paper›PMID 23197875›Full record

ArticleStem cells translational medicine2012

Mesenchymal stem cell transplantation improves regional cardiac remodeling following ovine infarction.

Yunshan Zhao, Tieluo Li, Xufeng Wei, Giacomo Bianchi, Jingping Hu, Pablo G Sanchez, Kai Xu, Pei Zhang, Mark F Pittenger, Zhongjun J Wu and 1 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
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  4. Review
  5. Review
  6. Article
  7. Stem Cell Therapies in Cardiovascular Disease.Journal of cardiothoracic and vascular anesthesia · 2019
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. "Second-generation" stem cells for cardiac repair.World journal of stem cells · 2015
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yunshan ZhaoDepartment of Surgery, University of Maryland, Baltimore, MD, USA.
Tieluo Li
Xufeng Wei
Giacomo Bianchi
Jingping Hu
Pablo G Sanchez
Kai Xu
Pei Zhang
Mark F Pittenger
Zhongjun J Wu
Bartley P Griffith
University of Maryland, Baltimore · US

Funding

Strain Controlled LVAD Unloading and Post MI RemodelingR01HL081106 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P · 2006 to 2010
$3.4M
NHLBI NIH HHS R01 HL081106NHLBI NIH HHS R01-HL081106
6 · The paper itself

Abstract

Progressive cardiac remodeling, including the myopathic process in the adjacent zone following myocardial infarction (MI), contributes greatly to the development of cardiac failure. Cardiomyoplasty using bone marrow-derived mesenchymal stem cells (MSCs) has been demonstrated to protect cardiomyocytes and/or repair damaged myocardium, leading to improved cardiac performance, but the therapeutic effects on cardiac remodeling are still under investigation. Here, we tested the hypothesis that MSCs could improve the pathological remodeling of the adjacent myocardium abutting the infarct. Allogeneic ovine MSCs were transplanted into the adjacent zone by intracardiac injection 4 hours after infarction. Results showed that remodeling and contractile strain alteration were reduced in the adjacent zone of the MSC-treated group. Cardiomyocyte hypertrophy was significantly attenuated with the normalization of the hypertrophy-related signaling proteins phosphatidylinositol 3-kinase α (PI3Kα), PI3Kγ, extracellular signal-regulated kinase (ERK), and phosphorylated ERK (p-ERK) in the adjacent zone of the MSC-treated group versus the MI-alone group. Moreover, the imbalance of the calcium-handling proteins sarcoplasmic reticulum Ca(2+) adenosine triphosphatase (SERCA2a), phospholamban (PLB), and sodium/calcium exchanger type 1 (NCX-1) induced by MI was prevented by MSC transplantation, and more strikingly, the activity of SERCA2a and uptake of calcium were improved. In addition, the upregulation of the proapoptotic protein Bcl-xL/Bcl-2-associated death promoter (BAD) was normalized, as was phospho-Akt expression; there was less fibrosis, as revealed by staining for collagen; and the apoptosis of cardiomyocytes was significantly inhibited in the adjacent zone by MSC transplantation. Collectively, these data demonstrate that MSC implantation improved the remodeling in the region adjacent to the infarct after cardiac infarction in the ovine infarction model.

Indexed as

Mesenchymal Stem Cell TransplantationVentricular RemodelingAnimalsApoptosisbcl-2-Associated X ProteinCalcium-Binding ProteinsCell DifferentiationCell ProliferationCells, CulturedClass II Phosphatidylinositol 3-KinasesDisease Models, AnimalExtracellular Signal-Regulated MAP KinasesFibrosisMesenchymal Stem CellsMyocardial InfarctionMyocardiumbcl-2-Associated X ProteinCalcium-Binding ProteinsClass II Phosphatidylinositol 3-KinasesExtracellular Signal-Regulated MAP KinasesPhospholambanProto-Oncogene Proteins c-aktSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Calcium Exchanger

Identifiers

PMID23197875
PMCPMC3659738
OpenAlexW2146156783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.