ArticleStem cells translational medicine2012
1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration.
Article in Stem cells translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Generation of Hair Follicle Germs In Vitro Using Human Postnatal Skin Cells.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Calcium and Vitamin D Supplementation with and Without Collagen on Bone Density and Skin Elasticity in Menopausal Women-A Randomized Controlled Study.Clinics and practice · 2025Article
- Parallel Toxicities: A Comparative Analysis of Chemotherapy-Induced Neutropenia and Alopecia.Cancers · 2025Review
- Comparative proteomic analysis of the telogen-to-anagen transition in cashmere goat secondary hair follicles.Frontiers in veterinary science · 2025Article
- Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells.Molecules (Basel, Switzerland) · 2023Review
- The role of WNT10B in physiology and disease: A 10-year update.Frontiers in cell and developmental biology · 2023Review
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration.Regenerative therapy · 2022Review
- Vitamin D supplementation and immune-related markers: an update from nutrigenetic and nutrigenomic studies.The British journal of nutrition · 2022Review
- Article
- A systematic summary of survival and death signalling during the life of hair follicle stem cells.Stem cell research & therapy · 2021Review
- Functional hair follicle regeneration: an updated review.Signal transduction and targeted therapy · 2021Review
- Trichotillomania associated with a 25-hydroxy vitamin D deficiency: A case report.The mental health clinician · 2020Article
- CRISPR/Cas9-mediatedPeerJ · 2019Article
- Article
- Chemotherapy-induced alopecia management: Clinical experience and practical advice.Journal of cosmetic dermatology · 2017Review
- Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid.Stem cells international · 2017Article
- Alteration of skin properties with autologous dermal fibroblasts.International journal of molecular sciences · 2014Review
- Female pattern alopecia: current perspectives.International journal of women's health · 2013Review
- Influence of Nutrition, Food Supplements and Lifestyle in Hair Disorders.Indian dermatology online journalReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dermal papilla cells (DPCs) have the potential to induce differentiation of epithelial stem cells into hair, and Wnt signaling is deeply involved in the initiation process. The functional limitation of expanded adult DPCs has been a difficult challenge for cell-based hair regrowth therapy. We previously reported that 1α,25-dihydroxyvitamin D(3) (VD(3)) upregulates expression of transforming growth factor (TGF)-β2 and alkaline phosphatase (ALP) activity, both features of hair-inducing human DPCs (hDPCs). In this study, we further examined the effects and signaling pathways associated with VD(3) actions on DPCs. VD(3) suppressed hDPC proliferation in a dose-dependent, noncytotoxic manner. Among the Wnt-related genes investigated, Wnt10b expression was significantly upregulated by VD(3) in hDPCs. Wnt10b upregulation, as well as upregulation of ALPL (ALP, liver/bone/kidney) and TGF-β2, by VD(3) was specific in hDPCs and not detected in human dermal fibroblasts. Screening of paracrine or endocrine factors in the skin indicated that all-trans retinoic acid (atRA) upregulated Wnt10b gene expression, although synergistic upregulation (combined atRA and VD(3)) was not seen. RNA interference with vitamin D receptor (VDR) revealed that VD(3) upregulation of Wnt10b, ALPL, and TGF-β2 was mediated through the genomic VDR pathway. In a rat model of de novo hair regeneration by murine DPC transplantation, pretreatment with VD(3) significantly enhanced hair folliculogenesis. Specifically, a greater number of outgrowing hair shafts and higher maturation of regenerated follicles were observed. Together, these data suggest that VD(3) may promote functional differentiation of DPCs and be useful in preserving the hair follicle-inductive capacity of cultured DPCs for hair regeneration therapies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.