ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Mechanisms generating dual-component nicotinic EPSCs in cortical interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Quantitative anatomy and biophysical modeling of ascending neuromodulatory systems in the developing rat neocortex.PLoS computational biology · 2026Article
- Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers.Neuron · 2022Article
- Cell-Type Specific Neuromodulation of Excitatory and Inhibitory NeuronsFrontiers in neural circuits · 2022Article
- Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing.Neuron · 2021Article
- Rapid multi-directed cholinergic transmission in the central nervous system.Nature communications · 2021Article
- αFrontiers in neural circuits · 2021Article
- Nicotinic receptor activation induces NMDA receptor independent long-term potentiation of glutamatergic signalling in hippocampal oriens interneurons.The Journal of physiology · 2021Article
- Cortical ChATeLife · 2020Article
- Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention.Nature communications · 2019Article
- Article
- Lateral inhibition by Martinotti interneurons is facilitated by cholinergic inputs in human and mouse neocortex.Nature communications · 2018Article
- Co-transmission of acetylcholine and GABA regulates hippocampal states.Nature communications · 2018Article
- Synaptic Release of Acetylcholine Rapidly Suppresses Cortical Activity by Recruiting Muscarinic Receptors in Layer 4.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Stoichiometry of the Heteromeric Nicotinic Receptors of the Renshaw Cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Molecular function of α7 nicotinic receptors as drug targets.The Journal of physiology · 2018Review
- Rapid Neuromodulation of Layer 1 Interneurons in Human Neocortex.Cell reports · 2018Article
- Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex.Cell reports · 2018Article
- Inhibitory circuit gating of auditory critical-period plasticity.Nature neuroscience · 2018Article
- Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex.Frontiers in neuroanatomy · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Activation of cortical nicotinic receptors by cholinergic axons from the basal forebrain (BF) significantly impacts cortical function, and the loss of nicotinic receptors is a hallmark of aging and neurodegenerative disease. We have previously shown that stimulation of BF axons generates a fast α7 and a slow non-α7 receptor-dependent response in cortical interneurons. However, the synaptic mechanisms that underlie this dual-component nicotinic response remain unclear. Here, we report that fast α7 receptor-mediated EPSCs in the mouse cortex are highly variable and insensitive to perturbations of acetylcholinesterase (AChE), while slow non-α7 receptor-mediated EPSCs are reliable and highly sensitive to AChE activity. Based on these data, we propose that the fast and slow nicotinic responses reflect differences in synaptic structure between cholinergic varicosities activating α7 and non-α7 classes of nicotinic receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.