ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis.Nature neuroscience · 2025Article
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- Different Ectopic Hoxa2 Expression Levels in Mouse Cranial Neural Crest Cells Result in Distinct Craniofacial Anomalies and Homeotic Phenotypes.Journal of developmental biology · 2022Article
- Diversification and Functional Evolution of HOX Proteins.Frontiers in cell and developmental biology · 2022Review
- Hoxa10 mediates positional memory to govern stem cell function in adult skeletal muscle.Science advances · 2021Article
- Roles ofFrontiers in cell and developmental biology · 2021Review
- Targeted chromatin conformation analysis identifies novel distal neural enhancers of ZEB2 in pluripotent stem cell differentiation.Human molecular genetics · 2020Article
- Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation.Neuro-oncology · 2020Article
- Genetic and Clinical Characterization of HOXB2 in Glioma.OncoTargets and therapy · 2020Article
- Overexpression of Truncated Human DISC1 Induces Appearance of Hindbrain Oligodendroglia in the Forebrain During Development.Schizophrenia bulletin · 2018Article
- Nuclear derivatives and axonal projections originating from rhombomere 4 in the mouse hindbrain.Brain structure & function · 2017Article
- Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells.Journal of neurochemistry · 2017Article
- Identification of proliferative progenitors associated with prominent postnatal growth of the pons.Nature communications · 2016Article
- Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination.PLoS genetics · 2015Article
- Osteogenesis and neurogenesis: a robust link also for language evolution.Frontiers in cellular neuroscience · 2015Article
- Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma.Translational psychiatry · 2014Article
- Review
- Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligodendrocytes are the myelin-forming cells of the vertebrate CNS. Little is known about the molecular control of region-specific oligodendrocyte development. Here, we show that oligodendrogenesis in the mouse rostral hindbrain, which is organized in a metameric series of rhombomere-derived (rd) territories, follows a rhombomere-specific pattern, with extensive production of oligodendrocytes in the pontine territory (r4d) and delayed and reduced oligodendrocyte production in the prepontine region (r2d, r3d). We demonstrate that segmental organization of oligodendrocytes is controlled by Hox genes, namely Hoxa2 and Hoxb2. Specifically, Hoxa2 loss of function induced a dorsoventral enlargement of the Olig2/Nkx2.2-expressing oligodendrocyte progenitor domain, whereas conditional Hoxa2 overexpression in the Olig2(+) domain inhibited oligodendrogenesis throughout the brain. In contrast, Hoxb2 deletion resulted in a reduction of the pontine oligodendrogenic domain. Compound Hoxa2(-/-)/Hoxb2(-/-) mutant mice displayed the phenotype of Hoxb2(-/-) mutants in territories coexpressing Hoxa2 and Hoxb2 (rd3, rd4), indicating that Hoxb2 antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis. This study provides the first in vivo evidence that Hox genes determine oligodendrocyte regional identity in the mammalian brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.