ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Consolidated and labile odor memory are separately encoded within the Drosophila brain.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Disruption of a selective vesicle pool upon retrograde amnesia dissociates memory at presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A temporally restricted function of the dopamine receptor Dop1R2 during memory formation.eLife · 2025Article
- Dynamics of two distinct memory interactions during water seeking inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies ofLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Genomes from historical Drosophila melanogaster specimens illuminate adaptive and demographic changes across more than 200 years of evolution.PLoS biology · 2023Article
- Article
- Anesthesia Resistant Memories in Drosophila, a Working Perspective.International journal of molecular sciences · 2022Review
- Review
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- A sperm peptide enhances long-term memory in femaleScience advances · 2019Article
- Forgetting memories through distinct actin remodeling mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila.PLoS genetics · 2019Article
- Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons.Neuron · 2018Article
- Dopamine and Serotonin Are Both Required for Mate-Copying inFrontiers in behavioral neuroscience · 2018Article
- Drk-mediated signaling to Rho kinase is required for anesthesia-resistant memory inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Two Components of Aversive Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets.PLoS genetics · 2016Article
Corrections and comments
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9 authors.
Funding
Abstract
Memories are classified as consolidated (stable) or labile according to whether they withstand amnestic treatment, or not. In contrast to the general prevalence of this classification, its neuronal and molecular basis is poorly understood. Here, we focused on consolidated and labile memories induced after a single cycle training in the Drosophila aversive olfactory conditioning paradigm and we used mutants to define the impact of cAMP signals. At the biochemical level we report that cAMP signals misrelated in either rutabaga (rut) or dunce (dnc) mutants separate between consolidated anesthesia-resistant memory (ARM) and labile anesthesia-sensitive memory (ASM). Those functionally distinct cAMP signals act within different neuronal populations: while rut-dependent cAMP signals act within Kenyon cells (KCs) of the mushroom bodies to support ASM, dnc-sensitive cAMP signals support ARM within antennal lobe local neurons (LNs) and KCs. Collectively, different key positions along the olfactory circuitry seem to get modified during storage of ARM or ASM independently. A precise separation between those functionally distinct cAMP signals seems mandatory to allocate how they support appropriate memories.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.