ArticleNucleic acids research2013
H-InvDB in 2013: an omics study platform for human functional gene and transcript discovery.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Advances in long noncoding RNAs: identification, structure prediction and function annotation.Briefings in functional genomics · 2016Review
- Gateways to the FANTOM5 promoter level mammalian expression atlas.Genome biology · 2015Article
- Differential Evolution approach to detect recent admixture.BMC genomics · 2015Article
- Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes.Human molecular genetics · 2014Article
- GeneSense: a new approach for human gene annotation integrated with protein-protein interaction networks.Scientific reports · 2014Article
- Lysine deacetylase (KDAC) regulatory pathways: an alternative approach to selective modulation.ChemMedChem · 2014Review
- BioHackathon series in 2011 and 2012: penetration of ontology and linked data in life science domains.Journal of biomedical semantics · 2014Article
- Alzheimer disease: An interactome of many diseases.Annals of Indian Academy of Neurology · 2014Article
- aLeaves facilitates on-demand exploration of metazoan gene family trees on MAFFT sequence alignment server with enhanced interactivity.Nucleic acids research · 2013Article
- Review: Alternative Splicing (AS) of Genes As An Approach for Generating Protein Complexity.Current genomics · 2013Article
- The 2013 Nucleic Acids Research Database Issue and the online molecular biology database collection.Nucleic acids research · 2013Article
- Transmembrane protein 208: a novel ER-localized protein that regulates autophagy and ER stress.PloS one · 2013Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H-InvDB (http://www.h-invitational.jp/) is a comprehensive human gene database started in 2004. In the latest version, H-InvDB 8.0, a total of 244 709 human complementary DNA was mapped onto the hg19 reference genome and 43 829 gene loci, including nonprotein-coding ones, were identified. Of these loci, 35 631 were identified as potential protein-coding genes, and 22 898 of these were identical to known genes. In our analysis, 19 309 annotated genes were specific to H-InvDB and not found in RefSeq and Ensembl. In fact, 233 genes of the 19 309 turned out to have protein functions in this version of H-InvDB; they were annotated as unknown protein functions in the previous version. Furthermore, 11 genes were identified as known Mendelian disorder genes. It is advantageous that many biologically functional genes are hidden in the H-InvDB unique genes. As large-scale proteomic projects have been conducted to elucidate the functions of all human proteins, we have enhanced the proteomic information with an advanced protein view and new subdatabase of protein complexes (Protein Complex Database with quality index). We propose that H-InvDB is an important resource for finding novel candidate targets for medical care and drug development.
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