ArticleMolecular biology and evolution2013
Evolution of dopamine receptor genes of the D1 class in vertebrates.
Article in Molecular biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Molecular mechanisms of native ligand selectivity in catecholamine G protein-coupled receptors.Nature communications · 2026Article
- Differences in the Effect of Dopamine on the Phototransduction Between Lampreys and Jawed Vertebrates.International journal of molecular sciences · 2026Article
- Comparative gene editing reduces dopamine receptor levels across rodent species.bioRxiv : the preprint server for biology · 2025Article
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Gap junction Delta-2b (Frontiers in cell and developmental biology · 2023Article
- The Acute Pharmacological Manipulation of Dopamine Receptors Modulates Judgment Bias in Japanese Quail.Frontiers in physiology · 2022Article
- Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.Nature communications · 2021Article
- Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.Frontiers in pharmacology · 2020Review
- Strategies for the Treatment of Parkinson's Disease: Beyond Dopamine.Frontiers in aging neuroscience · 2020Article
- Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes.Scientific reports · 2019Article
- Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity.Progress in neuro-psychopharmacology & biological psychiatry · 2018Article
- Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRDPeerJ · 2018Article
- Two dopamine D2-like receptor genes from the silkworm (Bombyx mori) and their evolutionary history in metazoan.Scientific reports · 2017Article
- Expression of a Novel D4 Dopamine Receptor in the Lamprey Brain. Evolutionary Considerations about Dopamine Receptors.Frontiers in neuroanatomy · 2015Article
- Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates.Frontiers in neuroscience · 2015Article
- Comprehensive, structurally-informed alignment and phylogeny of vertebrate biogenic amine receptors.PeerJ · 2015Article
- Article
- Molecular evolution of peptidergic signaling systems in bilaterians.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evolutionary history of chordate PAX genes: dynamics of change in a complex gene family.PloS one · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The receptors of the dopamine neurotransmitter belong to two unrelated classes named D1 and D2. For the D1 receptor class, only two subtypes are found in mammals, the D1A and D1B, receptors, whereas additional subtypes, named D1C, D1D, and D1X, have been found in other vertebrate species. Here, we analyzed molecular phylogeny, gene synteny, and gene expression pattern of the D1 receptor subtypes in a large range of vertebrate species, which leads us to propose a new view of the evolution of D1 dopamine receptor genes. First, we show that D1C and D1D receptor sequences are encoded by orthologous genes. Second, the previously identified Cypriniform D1X sequence is a teleost-specific paralog of the D1B sequences found in all groups of jawed vertebrates. Third, zebrafish and several sauropsid species possess an additional D1-like gene, which is likely to form another orthology group of vertebrate ancestral genes, which we propose to name D1E. Ancestral jawed vertebrates are thus likely to have possessed four classes of D1 receptor genes-D1A, D1B(X), D1C(D), and D1E-which arose from large-scale gene duplications. The D1C receptor gene would have been secondarily lost in the mammalian lineage, whereas the D1E receptor gene would have been lost independently in several lineages of modern vertebrates. The D1A receptors are well conserved throughout jawed vertebrates, whereas sauropsid D1C receptors have rapidly diverged, to the point that they were misidentified as D1D. The functional significance of the D1C receptor loss is not known. It is possible that the function may have been substituted with D1A or D1B receptors in mammals, following the disappearance of D1C receptors in these species.
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