ArticleMolecular biology of the cell2013
Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Ecdysone receptor autonomously controls germ cell differentiation in the Drosophila ovary.Development (Cambridge, England) · 2026Article
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- Loss-of-function in RBBP5 results in a syndromic neurodevelopmental disorder associated with microcephaly.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Article
- Coregulators Reside withinInternational journal of molecular sciences · 2023Article
- Transcriptional Activation of Ecdysone-Responsive Genes Requires H3K27 Acetylation at Enhancers.International journal of molecular sciences · 2022Article
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Nuclear receptors linking physiology and germline stem cells in Drosophila.Vitamins and hormones · 2021Review
- Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Regulation of neuronal survival by DNA methyltransferases.Neural regeneration research · 2017Review
- A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis.G3 (Bethesda, Md.) · 2016Article
- Diverse Hormone Response Networks in 41 Independent Drosophila Cell Lines.G3 (Bethesda, Md.) · 2016Article
- The ecdysone receptor coactivator Taiman links Yorkie to transcriptional control of germline stem cell factors in somatic tissue.Developmental cell · 2015Article
- Steroid signaling promotes stem cell maintenance in the Drosophila testis.Developmental biology · 2014Article
- Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function.The EMBO journal · 2014Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with transcriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdysone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr and is required for its stabilization. Thus we propose that Ash2 functions together with Trr as an ecdysone receptor coactivator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.