ArticleJournal of neurophysiology2013
Short-term plasticity shapes activity pattern-dependent striato-pallidal synaptic transmission.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Comparison of unitary synaptic currents generated by indirect and direct pathway neurons of the mouse striatum.Journal of neurophysiology · 2024Article
- Endocannabinoids and Dopamine Balance Basal Ganglia Output.Frontiers in cellular neuroscience · 2021Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons.The Journal of physiology · 2018Article
- The role of cortical oscillations in a spiking neural network model of the basal ganglia.PloS one · 2017Article
- Posttetanic enhancement of striato-pallidal synaptic transmission.Journal of neurophysiology · 2015Article
- Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.Journal of neurophysiology · 2013Article
- Review: electrophysiology of basal ganglia and cortex in models of Parkinson disease.Journal of Parkinson's disease · 2013Review
Corrections and comments
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2 authors.
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Abstract
The cortico-striato (Str)-globus pallidus external segment (GPe) projection plays major roles in the control of neuronal activity in the basal ganglia under both normal and pathological conditions. The present study used rat brain-slice preparations to address our hypothesis that the gain of this disynaptic projection is dynamically controlled by activations of short-term plasticity mechanisms of Str-GPe synapses. The Str-GPe projection neurons fire with very different frequency and firing patterns in vivo depending on the condition of the animal. The results show that the Str-GPe synapses have very strong short-term enhancement mechanisms and that repetitive burst activation of the Str-GPe synapses, which mimic oscillatory burst firing of Str neurons, can sustain enhanced states of synaptic transmission for tens of seconds. The results reveal that the short-term enhancement of Str-GPe synapses contributes to the generation of pauses in the firing of GPe neurons and that signal transfer function in the Str-GPe projection is highly dependent on the firing pattern of Str neurons.
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