ArticleJournal of neurophysiology2013
Corticospinal excitability is enhanced after visuomotor adaptation and depends on learning rather than performance or error.
Article in Journal of neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01072461 (Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments
Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Acute pain impairs retention of locomotor learning, regardless of the context of retention testing.Journal of neurophysiology · 2025Trial
- Enhanced motor learning and motor savings after acute intermittent hypoxia are associated with a reduction in metabolic cost.The Journal of physiology · 2024Trial
- Acute pain impairs retention of locomotor learning.Journal of neurophysiology · 2024Trial
- Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023Trial
- Trial
- Two distinct interneuron circuits in human motor cortex are linked to different subsets of physiological and behavioral plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Trial
- Acute pain impairs locomotor learning and retention in older adults.The journal of pain · 2026Article
- Evoked potentials in stroke rehabilitation: current applications, emerging technologies, and future directions.Frontiers in neuroscience · 2026Review
- Intermittent hypoxia-induced enhancements in corticospinal excitability predict gains in motor learning and metabolic efficiency.Scientific reports · 2025Article
- Is there a link between motor learning and mirror neuron system: TMS study.Frontiers in human neuroscience · 2025Article
- Hebbian priming of human motor learning.Nature communications · 2024Article
- Intermittent Hypoxia-Induced Enhancements in Corticospinal Excitability Predict Gains in Motor Learning and Metabolic Efficiency.Research square · 2024Article
- Changes in Corticospinal Excitability and Motor Control During Cerebellar Transcranial Direct Current Stimulation in Healthy Individuals.Cerebellum (London, England) · 2023Article
- A Serious Game for the Assessment of Visuomotor Adaptation Capabilities during Locomotion Tasks Employing an Embodied Avatar in Virtual Reality.Sensors (Basel, Switzerland) · 2023Article
- Direct and indirect effects of cathodal cerebellar TDCS on visuomotor adaptation of hand and arm movements.Scientific reports · 2021Article
- Use-Dependent Plasticity in Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Corticospinal excitability is modulated by temporal feedback gaps.Neuroreport · 2018Article
- Differential plasticity of extensor and flexor motor cortex representations following visuomotor adaptation.Experimental brain research · 2018Article
- Corticospinal correlates of fast and slow adaptive processes in motor learning.Journal of neurophysiology · 2018Article
- Parietal Activation Associated With Target-Directed Right Hand Movement Is Lateralized by Mirror Feedback to the Ipsilateral Hemisphere.Frontiers in human neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We used adaptation to high and low gains in a virtual reality setup of the hand to test competing hypotheses about the excitability changes that accompany motor learning. Excitability was assayed through changes in amplitude of motor evoked potentials (MEPs) in relevant hand muscles elicited with single-pulse transcranial magnetic stimulation (TMS). One hypothesis is that MEPs will either increase or decrease, directly reflecting the effect of low or high gain on motor output. The alternative hypothesis is that MEP changes are not sign dependent but rather serve as a marker of visuomotor learning, independent of performance or visual-to-motor mismatch (i.e., error). Subjects were required to make flexion movements of a virtual forefinger to visual targets. A gain of 1 meant that the excursions of their real finger and virtual finger matched. A gain of 0.25 ("low gain") indicated a 75% reduction in visual versus real finger displacement, a gain of 1.75 ("high gain") the opposite. MEP increases (>40%) were noted in the tonically activated task-relevant agonist muscle for both high- and low-gain perturbations after adaptation reached asymptote with kinematics matched to veridical levels. Conversely, only small changes in excitability occurred in a control task of pseudorandom gains that required adjustments to large errors but in which learning could not accumulate. We conclude that changes in corticospinal excitability are related to learning rather than performance or error.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.