ArticleHippocampus2013
Divergent cellular pathways of hippocampal memory consolidation and reconsolidation.
Article in Hippocampus, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus.PloS one · 2019Pooled it
- Assessing the translational feasibility of pharmacological drug memory reconsolidation blockade with memantine in quitting smokers.Psychopharmacology · 2015Trial
- Randomized Placebo-Controlled Trial of Memantine for Smoking Cessation (CCCWFU 99311).Cancer control : journal of the Moffitt Cancer CenterTrial
- Differential effects of cannabidiol on inhibitory avoidance memory reconsolidation and consolidation are associated with distinct hippocampal proBDNF and BDNF signaling profiles.Frontiers in neuroscience · 2026Article
- Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence.Neuroscience and biobehavioral reviews · 2025Review
- How Fear Memory is Updated: From Reconsolidation to Extinction?Neuroscience bulletin · 2025Review
- Cellular mechanisms of contextual fear memory reconsolidation: Role of hippocampal SFKs, TrkB receptors and GluN2B-containing NMDA receptors.Psychopharmacology · 2024Article
- Social memory in female mice is rapidly modulated by 17β-estradiol through ERK and Akt modulation of synapse formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Elevation of EGR1/zif268, a Neural Activity Marker, in the Auditory Cortex of Patients with Schizophrenia and its Animal Model.Neurochemical research · 2022Article
- Continuous theta-burst stimulation over the right dorsolateral prefrontal cortex disrupts fear memory reconsolidation in humans.iScience · 2022Article
- The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.Molecular psychiatry · 2021Article
- Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording.Micromachines · 2021Article
- Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.Psychopharmacology · 2021Article
- Behavioral and brain- transcriptomic synchronization between the two opponents of a fighting pair of the fish Betta splendens.PLoS genetics · 2020Article
- Recognition memory reconsolidation requires hippocampal Zif268.Scientific reports · 2019Article
- Brain-derived neurotrophic factor: A steroidogenic regulator of Leydig cells.Journal of cellular physiology · 2019Article
- Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Kinase and Phosphatase Engagement Is Dissociated Between Memory Formation and Extinction.Frontiers in molecular neuroscience · 2019Article
- On the Involvement of BDNF Signaling in Memory Reconsolidation.Frontiers in cellular neuroscience · 2019Review
- Neurochemical and molecular mechanisms underlying the retrieval-extinction effect.Psychopharmacology · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The reconsolidation of memories after their retrieval involves cellular mechanisms that recapitulate much of the initial consolidation process. However, we have previously demonstrated that there are independent cellular mechanisms of consolidation and reconsolidation in the dorsal hippocampus for contextual fear memories. Expression of BDNF was required for consolidation, while Zif268 expression was necessary for reconsolidation. Given the dichotomy between the obvious mechanistic similarity and notable dissociations between consolidation and reconsolidation, we sought to determine whether the separation at the level of gene expression reflected either parallel and independent upstream signaling pathways, or common upstream mechanisms that diverge by the level of transcriptional activation. Here we show that while consolidation and reconsolidation are commonly dependent upon NMDA receptor activation in the dorsal hippocampus there is a double dissociation between the effects of the MEK inhibitor U0126 and the IKK inhibitor sulfasalazine. Moreover, rescue experiments and western blot analyses show that there are functional NMDA receptor-ERK1-BDNF and NMDA receptor-IKKα-Zif268 pathways for consolidation and reconsolidation, respectively. Therefore, there are divergent pathways of hippocampal memory consolidation and reconsolidation, involving commonality at the cell surface, but separable downstream kinase cascades and transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.