ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013
Increased mandibular condylar growth in mice with estrogen receptor beta deficiency.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Mandibular Condylar Cartilage in Development and Diseases: A PTHrP-Centric View.Orthodontics & craniofacial research · 2025Review
- Sex-dependent variation in cartilage adaptation: from degeneration to regeneration.Biology of sex differences · 2023Review
- Impact of estrogen therapy on temporomandibular joints of rats: Histological and hormone analytical study.The Saudi dental journal · 2021Article
- Estrogen signaling impacts temporomandibular joint and periodontal disease pathology.Odontology · 2020Review
- Lipid profiles as potential mediators linking body mass index to osteoporosis among Chinese adults: the Henan Rural Cohort Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Estrogen Promotes Mandibular Condylar Fibrocartilage Chondrogenesis and Inhibits Degeneration via Estrogen Receptor Alpha in Female Mice.Scientific reports · 2018Article
- Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway.BioMed research international · 2018Article
- Association of Condylar Bone Quality with TMJ Osteoarthritis.Journal of dental research · 2017Article
- Estrogen receptor alpha mediates mandibular condylar cartilage growth in male mice.Orthodontics & craniofacial research · 2017Article
- Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading.Osteoarthritis and cartilage · 2017Article
- The obesity of bone.Therapeutic advances in endocrinology and metabolism · 2015Review
- Oestrogen receptor beta mediates decreased occlusal loading induced inhibition of chondrocyte maturation in female mice.Archives of oral biology · 2015Article
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.Osteoarthritis and cartilage · 2014Article
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7 authors.
Funding
Abstract
Temporomandibular joint (TMJ) disorders predominantly afflict women of childbearing age, suggesting a role for female hormones in the disease process. In long bones, estrogen acting via estrogen receptor beta (ERβ) inhibits axial skeletal growth in female mice. However, the role of ERβ in the mandibular condyle is largely unknown. We hypothesize that female ERβ-deficient mice will have increased mandibular condylar growth compared to wild-type (WT) female mice. This study examined female 7-day-old, 49-day-old, and 120-day-old WT and ERβ knockout (KO) mice. There was a significant increase in mandibular condylar cartilage thickness as a result of an increased number of cells, in the 49-day-old and 120-day-old female ERβ KO compared with WT controls. Analysis in 49-day-old female ERβ KO mice revealed a significant increase in collagen type X, parathyroid hormone-related protein (Pthrp), and osteoprotegerin gene expression and a significant decrease in receptor activator for nuclear factor κ B ligand (Rankl) and Indian hedgehog (Ihh) gene expression, compared with WT controls. Subchondral bone analysis revealed a significant increase in total condylar volume and a decrease in the number of osteoclasts in the 49-day-old ERβ KO compared with WT female mice. There was no difference in cell proliferation in condylar cartilage between the genotypes. However, there were differences in the expression of proteins that regulate the cell cycle; we found a decrease in the expression of Tieg1 and p57 in the mandibular condylar cartilage from ERβ KO mice compared with WT mice. Taken together, our results suggest that ERβ deficiency increases condylar growth in female mice by inhibiting the turnover of fibrocartilage.
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