Evidence map›Paper›PMID 23197273›Full record

ReviewCancer immunology, immunotherapy : CII2013

Personalized peptide vaccination: a new approach for advanced cancer as therapeutic cancer vaccine.

Masanori Noguchi, Tetsuro Sasada, Kyogo Itoh

Abstract readReview
In one paragraph

Review in Cancer immunology, immunotherapy : CII, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

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  12. Frequencies of an Immunogenic HER-2/International journal of molecular sciences · 2023
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  13. Review
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  16. Development of Cancer Immunotherapies.Cancer treatment and research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masanori NoguchiDepartment of Urology, Kurume University School of Medicine, Kurume, Japan. noguchi@med.kurume-u.ac.jp
Tetsuro Sasada
Kyogo Itoh

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since both tumor cells and host immune cell repertoires are diverse and heterogeneous, immune responses against tumor-associated antigens should differ substantially among individual cancer patients. Selection of suitable peptide vaccines for individual patients based on the preexisting host immunity before vaccination could induce potent anti-tumor responses that provide clinical benefit to cancer patients. We have developed a novel immunotherapeutic approach of personalized peptide vaccination (PPV) in which a maximum of four human leukocyte antigen (HLA) class IA-matched peptides are selected for vaccination among pooled peptides on the basis of both HLA class IA type and the preexisting host immunity before vaccination. In this review, we discuss our recent results of preclinical and clinical studies of PPV for various types of advanced cancer.

Indexed as

Antigens, NeoplasmCancer VaccinesCell Line, TumorClinical Trials as TopicHLA AntigensHumansImmunotherapyMedical OncologyNeoplasmsPrecision MedicineTime FactorsVaccines, SubunitAntigens, NeoplasmCancer VaccinesHLA AntigensVaccines, Subunit

Identifiers

PMID23197273
PMCPMC11029009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.