ArticleAnais brasileiros de dermatologia
HLA-B27 frequency in a group of patients with psoriatic arthritis.
Article in Anais brasileiros de dermatologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Exploring the phenotypic expression of HLA-B27 in psoriatic arthritis.Clinical rheumatology · 2026Article
- Allelic and haplotypic HLA analysis in patients with psoriatic arthritis: Low frequency of common allelesBiomedica : revista del Instituto Nacional de Salud · 2024Article
- The Role of Epigenetic Factors in the Pathogenesis of Psoriasis.International journal of molecular sciences · 2024Review
- Current characteristics of a population of psoriatic arthritis and gender disparities.Journal of clinical and translational research · 2023Article
- The Role of the IL-23/IL-17 Pathway in the Pathogenesis of Spondyloarthritis.International journal of molecular sciences · 2020Review
- Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients.Frontiers in medicine · 2020Article
- Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients.Frontiers in genetics · 2019Review
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Authors and funding
3 authors.
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Abstract
backgroundHLA-B27 is associated with spondyloarthritis, a group of diseases that includes psoriatic arthritis.
objectivesTo describe the HLA-B27 frequency in a group of Brazilian patients with psoriatic arthritis and correlate its presence or absence with their clinical manifestations.
methodsCross-sectional study with 44 psoriatic arthritis patients of a Rheumatology clinic. Demographic and social data were recorded, as were skin and joints clinical examination. HLA-B27 was tested. All data were processed descriptively and comparatively by appropriate software. Parametric and non parametric tests were used with 5% statistical significance.
resultsHLA-B27 was negative in 32 of the 44 patients (72,7%). Most of them were male, Caucasian, living in Rio de Janeiro, with plaque type psoriasis and average age of 52,9 years. There was statistical significant correlation between positive HLA-B27 and male gender (p=0,004). Negative HLA-B27 had a tendency to correlate with hands and wrists arthritis (p=0,07). There was an inverse significant correlation between HLA values and Schöber's test (p=0,02).
conclusionAlthough HLA-B27 is negative in most of patients, it is significantly associated to male gender and inversely correlated with Schöber's test.
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