Evidence map›Paper›PMID 23196988›Full record

ArticleBioinformatics (Oxford, England)2013

NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse.

Yaping Fang, Hui-Xin Liu, Ning Zhang, Grace L Guo, Yu-Jui Yvonne Wan, Jianwen Fang

Open access · hybridAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Retinoic acid and microRNA.Methods in enzymology · 2020
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yaping FangApplied Bioinformatics Laboratory, University of Kansas, Lawrence, KS 66047, USA. jwfang@ku.edu
Hui-Xin Liu
Ning Zhang
Grace L Guo
Yu-Jui Yvonne Wan
Jianwen Fang
University of Kansas · USRutgers, The State University of New Jersey · USTianjin University · CN

Funding

Retinoids Xenobiotic Metabolism and Tumor PromotionR01CA053596 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WAN, YU-JUI YVONNE · 1996 to 2014
$4.5M
Retinoic Acid, Its Receptors, and the LiverR01DK092100 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WAN, YU-JUI YVONNE · 2011 to 2014
$1.4M
FXR, nuclear receptors, and transcriptional regulation of liver homeostasisR56DK090036 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI GUO, GRACE L · 2011 to 2011
$328k
RETINOIC ACID RECEPTOR ALPHA-FETOPROTEIN AND HEPATOMAR29CA053596 · NCI · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI WAN, YU-JUI YVONNE · 1991 to 1995
–
NCI NIH HHS CA53596NCI NIH HHS R01 CA053596NIDDK NIH HHS DK090036NIDDK NIH HHS DK092100NIDDK NIH HHS R01 DK092100NIDDK NIH HHS R56 DK090036
6 · The paper itself

Abstract

summaryNuclear receptors (NRs) are a class of transcription factors playing important roles in various biological processes. An NR often impacts numerous genes and different NRs share overlapped target networks. To fulfil the need for a database incorporating binding sites of different NRs at various conditions for easy comparison and visualization to improve our understanding of NR binding mechanisms, we have developed NURBS, a database for experimental and predicted nuclear receptor binding sites of mouse (NURBS). NURBS currently contains binding sites across the whole-mouse genome of 8 NRs identified in 40 chromatin immunoprecipitation with massively parallel DNA sequencing experiments. All datasets are processed using a widely used procedure and same statistical criteria to ensure the binding sites derived from different datasets are comparable. NURBS also provides predicted binding sites using NR-HMM, a Hidden Markov Model (HMM) model. AVAILABILITY: The GBrowse-based user interface of NURBS is freely accessible at http://shark.abl.ku.edu/nurbs/. NR-HMM and all results can be downloaded for free at the website. CONTACT: jwfang@ku.edu

Indexed as

Databases, GeneticAnimalsBinding SitesCell NucleusChromatin ImmunoprecipitationGenomeHigh-Throughput Nucleotide SequencingMarkov ChainsMiceReceptors, Cytoplasmic and NuclearSequence Analysis, DNAReceptors, Cytoplasmic and Nuclear

Identifiers

PMID23196988
PMCPMC3546791
OpenAlexW2157959969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.