ArticleApplied microbiology and biotechnology2013
Isolation, biochemical characterization, and cloning of a bacteriocin from the poultry-associated Staphylococcus aureus strain CH-91.
Article in Applied microbiology and biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 40 citations in OpenAlex.
- Interactions ofInternational journal of molecular sciences · 2025Article
- Genomic Analysis of Bacteriocin-Producing Staphylococci: High Prevalence of Lanthipeptides and the Micrococcin P1 Biosynthetic Gene Clusters.Probiotics and antimicrobial proteins · 2025Article
- In Vitro and In Silico Characterization of N-Formylated Two-Peptide Bacteriocin from Enterococcus faecalis CAUM157 with Anti-Listeria Activity.Probiotics and antimicrobial proteins · 2024Article
- The role of proteinaceous toxins secreted byFEMS microbes · 2024Review
- Comprehensive Approaches for the Search and Characterization of Staphylococcins.Microorganisms · 2023Article
- BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Article
- Bacteriocin BacSp222 and Its Succinylated Forms Exhibit Proinflammatory Activities Toward Innate Immune Cells .Journal of inflammation research · 2022Article
- Bacteriocin-Like Inhibitory Substances in Staphylococci of Different Origins and Species With Activity Against Relevant Pathogens.Frontiers in microbiology · 2022Article
- Structure, Biosynthesis, and Biological Activity of Succinylated Forms of Bacteriocin BacSp222.International journal of molecular sciences · 2021Article
- Exploring clinically isolatedIranian journal of microbiology · 2021Article
- Antifungal Activity of Anionic Defense Peptides: Insight into the Action ofInternational journal of molecular sciences · 2020Article
- Staphylococcal-Produced Bacteriocins and Antimicrobial Peptides: Their Potential as Alternative Treatments forAntibiotics (Basel, Switzerland) · 2020Review
- Identification and characterisation of capidermicin, a novel bacteriocin produced by Staphylococcus capitis.PloS one · 2019Article
- Identification of Putative Novel Class-I Lanthipeptides in Firmicutes: A CombinatorialInternational journal of molecular sciences · 2018Article
- A peptide factor secreted by Staphylococcus pseudintermedius exhibits properties of both bacteriocins and virulence factors.Scientific reports · 2015Article
- Using the overlay assay to qualitatively measure bacterial production of and sensitivity to pneumococcal bacteriocins.Journal of visualized experiments : JoVE · 2014Article
- Review
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus strain CH-91, isolated from a broiler chicken with atopic dermatitis, has a highly proteolytic phenotype that is correlated with the disease. We describe the isolation and biochemical and molecular characterization of the AI-type lantibiotic BacCH91 from S. aureus CH-91 culture medium. The bacteriocin was purified using a three-stage procedure comprising precipitation with ammonium sulfate, extraction with organic solvents, and reversed-phase HPLC. The BacCH91 peptide is thermostable and highly resistant to cleavage by both prokaryotic and eukaryotic peptidases. The MIC for the Gram-positive bacteria ranged from 2.5 nM for Microococcus luteus through 1.3-6.0 μM for staphylococcal strains up to more than 100 μM for Lactococcus lactis. BacCH91 was ineffective against the Gram-negative strains tested at the maximal concentration (100 μM). The amino acid sequence of BacCH91 is similar to that of epidermin and gallidermin. The encoding gene (bacCH91) occurred in two allelic variants distinguishable in the restriction fragment length polymorphism assay. Variant I, identified in S. aureus CH-91, dominated in S. aureus strains of poultry origin, although strains with variant II were also identified in this group. S. aureus strains of human origin were characterized exclusively by variant II.
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