ArticleInternational journal of radiation oncology, biology, physics2013
Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.
Article in International journal of radiation oncology, biology, physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Influenza A Virus after Radiotherapy Amplifies Lung Injury and Monocyte-derived Macrophage Responses.American journal of respiratory cell and molecular biology · 2026Article
- Mitigating Viral Impact on the Radiation Response of the Lung.Radiation research · 2024Article
- Selecting the Most Relevant Mouse Strains for Evaluating Radiation-Induced Multiple Tissue Injury after Leg-Shielded Partial-Body Gamma Irradiation.Radiation research · 2024Article
- Leptin Receptor Deficiency Impairs Lymph Node Development and Adaptive Immune Response.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- All for one, though not one for all: team players in normal tissue radiobiology.International journal of radiation biology · 2022Review
- Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?Radiation research · 2020Review
- Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.Radiation research · 2016Review
- Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Examining the Effects of External or Internal Radiation Exposure of Juvenile Mice on Late Morbidity after Infection with Influenza A.Radiation research · 2015Article
- Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein.Radiation research · 2013Article
- SARS-CoV-2 Spike Protein Induces Oxidative Stress and Senescence in Mouse and Human Lung.In vivo (Athens, Greece)Article
- Low-dose radiation therapy for coronavirus disease-2019 pneumonia: Is it time to look beyond apprehensions?Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo address whether irradiation-induced changes in the lung environment alter responses to a viral challenge delivered late after exposure but before the appearance of late lung radiation injury. METHODS AND MATERIALS: C57BL/6J mice received either lung alone or combined lung and whole-body irradiation (0-15 Gy). At 10 weeks after irradiation, animals were infected with 120 HAU influenza virus strain A/HKx31. Innate and adaptive immune cell recruitment was determined using flow cytometry. Cytokine and chemokine production and protein leakage into the lung after infection were assessed.
resultsPrior irradiation led to a dose-dependent failure to regain body weight after infection and exacerbated mortality, but it did not affect virus-specific immune responses or virus clearance. Surviving irradiated animals displayed a persistent increase in total protein in bronchoalveolar lavage fluid and edema.
conclusionsLung irradiation increased susceptibility to death after infection with influenza virus and impaired the ability to complete recovery. This altered response does not seem to be due to a radiation effect on the immune response, but it may possibly be an effect on epithelial repair.
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