ArticleAmerican journal of physiology. Renal physiology2013
Reduced ENaC activity and blood pressure in mice with genetic knockout of the insulin receptor in the renal collecting duct.
Article in American journal of physiology. Renal physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Functional Connections Between Insulin and Neurotrophin-3 in Hemodialysis Patients with Type 2 Diabetes.Current issues in molecular biology · 2026Review
- Understanding Insulin Actions Beyond Glycemic Control: A Narrative Review.Journal of clinical medicine · 2025Review
- Insulin receptor orchestrates kidney antibacterial defenses.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sex Modulates Response to Renal-Tubule-Targeted Insulin Receptor Deletion in Mice.International journal of molecular sciences · 2023Article
- Insulin and the kidneys: a contemporary view on the molecular basis.Frontiers in nephrology · 2023Review
- Insulin Resistance and High Blood Pressure: Mechanistic Insight on the Role of the Kidney.Biomedicines · 2022Review
- Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.JCI insight · 2021Article
- Sorting nexin 1 loss results in increased oxidative stress and hypertension.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Insulin: Trigger and Target of Renal Functions.Frontiers in cell and developmental biology · 2020Review
- Postprandial effects on electrolyte homeostasis in the kidney.American journal of physiology. Renal physiology · 2019Review
- Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.The Journal of clinical investigation · 2018Article
- Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice.International journal of molecular sciences · 2018Article
- Renal tubule insulin receptor modestly promotes elevated blood pressure and markedly stimulates glucose reabsorption.JCI insight · 2018Article
- The Evolving Importance of Insulin Signaling in Podocyte Health and Disease.Frontiers in endocrinology · 2018Review
- The normal increase in insulin after a meal may be required to prevent postprandial renal sodium and volume losses.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The impact of insulin resistance on the kidney and vasculature.Nature reviews. Nephrology · 2016Review
- New perspective of ClC-Kb/2 Cl- channel physiology in the distal renal tubule.American journal of physiology. Renal physiology · 2016Review
- Na+-sensitive elevation in blood pressure is ENaC independent in diet-induced obesity and insulin resistance.American journal of physiology. Renal physiology · 2016Article
- Paediatrics, insulin resistance and the kidney.Pediatric nephrology (Berlin, Germany) · 2015Review
- Cross-talk between insulin and IGF-1 receptors in the cortical collecting duct principal cells: implication for ENaC-mediated Na+ reabsorption.American journal of physiology. Renal physiology · 2015Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
To elucidate the role of the insulin receptor (IR) in collecting duct (CD), we bred mice with IR selectively deleted from CD principal cells using an aquaporin-2 promoter to drive Cre-recombinase expression. Young, adult male knockout (KO) mice had altered plasma and electrolyte homeostasis under high- (HS) and low-sodium (LS) diets, relative to wild-type (WT) littermates. One week of LS feeding led to a significant reduction in urine potassium (K(+)) and sodium (Na(+)) excretion in KO, and a reduction in the ratio of Na(+) to chloride (Cl(-)) in plasma, relative to WT. HS diet (1 wk) increased plasma K(+) and reduced urine Na(+) to Cl(-) ratio in the KO. Furthermore, KO mice had a significantly (P = 0.025) blunted natriuretic response to benzamil, an epithelial sodium channel (ENaC) antagonist. Western blotting of cortex homogenates revealed modestly, but significantly (∼15%), lower band density for the β-subunit of ENaC in the KO vs. WT mice, with no differences for the α- or γ-subunits. Moreover, blood pressure (BP), measured by radiotelemetry, was significantly lower in KO vs. WT mice under basal conditions (mmHg): 112 ± 5 (WT), 104 ± 2 (KO), P = 0.023. Chronic insulin infusion reduced heart rate in the WT, but not in the KO, and modestly reduced BP in the WT only. Overall, these results support a fundamental role for insulin through its classic receptor in the modulation of electrolyte homeostasis and BP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.