Evidence map›Paper›PMID 23195314›Full record

ReviewInternational review of neurobiology2012

Genetic and molecular network analysis of behavior.

Robert W Williams, Megan K Mulligan

Abstract readReview
In one paragraph

Review in International review of neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  4. Article
  5. Systems Genetic Analysis in GeneNetwork.org.Current protocols in neuroscience · 2017
    Article
  6. Article
  7. GeneNetwork: A Toolbox for Systems Genetics.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Genetics of gene expression in CNS.International review of neurobiology · 2014
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert W WilliamsDepartment of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, USA. rwilliams@uthsc.edu
Megan K Mulligan

Funding

MOUSE BIRNU24RR021760 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2005 to 2009
$11.6M
Modeling heterogeneity for safe cancer prevention and detectionU01CA105417 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THREADGILL, DAVID W. · 2004 to 2013
$6.7M
Informatics Center for Mouse NeurogeneticsP20DA021131 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2005 to 2009
$5.0M
Systems Genetics of Alcohol Response and Stress Effects in CNSU01AA013499 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2002 to 2016
$4.8M
INIA-STRESS: Informatics and Analysis CoreU01AA016662 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILLIAMS, ROBERT W. · 2007 to 2016
$2.9M
Genetic Analysis of Ethanol-Mediated Stress ReductionU01AA014425 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU · 2004 to 2008
$2.1M
Systems Genetics of the HPAU01AA017590 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2008 to 2011
$912k
INIA: Genotyping CoreU01AA013513 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLLIAMS, ROBERT W · 2002 to 2006
$753k
NCI NIH HHS U01 CA105417NCI NIH HHS U01CA105417NCRR NIH HHS U24 RR021760NIAAA NIH HHS U01 AA013499NIAAA NIH HHS U01 AA013513NIAAA NIH HHS U01 AA014425NIAAA NIH HHS U01 AA016662NIAAA NIH HHS U01 AA017590NIAAA NIH HHS U01 AA16662NIAAA NIH HHS U24 AA013513NIDA NIH HHS P20 DA021131NIDA NIH HHS P20-DA 21131
6 · The paper itself

Abstract

This chapter provides an introduction into the genetic control and analysis of behavioral variation using powerful online resources. We introduce you to the new field of systems genetics using "case studies" drawn from the world of behavioral genetics that exploit populations of genetically diverse lines of mice. These lines differ very widely in patterns of gene and protein expression in the brain and in patterns of behavior. In this chapter, we address the following set of related questions: (1) Can we combine massive genomic data sets with large aggregates of precise quantitative data on behavior? (2) Can we map causal relations between gene variants and behavioral differences? (3) Can we simultaneously use these highly coherent data sets to understand more about the underlying molecular and cellular basis of behavior?

Indexed as

Gene Regulatory NetworksGenetics, BehavioralQuantitative Trait LociAnimalsBehaviorGene Expression RegulationGenetic VariationGenomeGenotypeHumansPhenotype

Identifiers

PMID23195314
PMCPMC4267574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.