ArticleAJNR. American journal of neuroradiology2013
Clopidogrel resistance is associated with thromboembolic complications in patients undergoing neurovascular stenting.
Article in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
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Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.
- Ventriculostomy-related hemorrhage in patients on antiplatelet therapy for endovascular treatment of acutely ruptured intracranial aneurysms. A meta-analysis.Neurosurgical review · 2020Pooled it
- Short- versus long-term Dual AntiPlatelet Therapy for Stent-Assisted treatment of CErebral aneurysm (DAPTS ACE): a multicenter, open-label, randomized clinical trial.Journal of neurointerventional surgery · 2024Trial
- Intracranial stenting for large vessel intracranial atherosclerotic disease: Retrospective study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Drug response testing for elective carotid artery stenting: Prevalence of non-response to aspirin and clopidogrel and influence on post-interventional occurrence of cerebral ischemia.The neuroradiology journal · 2026Article
- The Utility of Antiplatelet Assay-Guided Individualized Dual Antiplatelet Therapy in Carotid Artery Stenting for Unstable Plaques.Journal of Korean Neurosurgical Society · 2026Article
- Staged coiling and flow diversion for a ruptured persistent primitive hypoglossal artery aneurysm: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Overcoming Clopidogrel Resistance in Carotid Artery Stenting: Experience with Ticagrelor and Ticlopidine.Clinics and practice · 2026Article
- Stent-Assisted Coil Embolization for Ruptured Wide-Neck Aneurysms in the Acute Phase of Subarachnoid Hemorrhage: A Single-Center Experience in Japan.Journal of neuroendovascular therapy · 2026Article
- Role of thromboelastography in predicting stroke risk after endovascular treatment for symptomatic intracranial atherosclerotic stenosis.European journal of medical research · 2025Article
- Prophylactic administration of tirofiban prevents ischemic events in endovascular treatment of unruptured intracranial aneurysms.Neurosurgical review · 2025Article
- Antithrombotic Therapy in Carotid Artery and Intracranial Artery Stent.Journal of neuroendovascular therapy · 2025Review
- Antiplatelet Therapy and Platelet Activity Testing for Neurointerventional Procedures.Stroke (Hoboken, N.J.) · 2025Review
- Platelet aggregation rate serves as a significant predictive indicator for thromboembolic events in the context of stent-assisted embolization for unruptured arterial aneurysms.Frontiers in neurology · 2025Article
- Platelet-Function-Monitoring-Guided Therapy After Emergent Carotid Artery Stenting.Journal of clinical medicine · 2024Article
- The SAFEST Study: Survey on Antiplatelets in Flow Diversion for Aneurysm Endovascular Treatment.Stroke (Hoboken, N.J.) · 2024Article
- Outcome of tailored antiplatelet therapy in carotid stenting: a retrospective comparative study.CVIR endovascular · 2024Article
- Subacute in-stent thrombosis after carotid artery stenting in a patient with gene polymorphisms associated with aspirin and clopidogrel resistance: a case report.Thrombosis journal · 2024Article
- Managing Clopidogrel Resistance in Neurointervention: Surveying Current Approaches.Stroke (Hoboken, N.J.) · 2024Article
- Prasugrel Single Antiplatelet Therapy versus Aspirin and Clopidogrel Dual Antiplatelet Therapy for Flow Diverter Treatment for Cerebral Aneurysms: A Retrospective Multicenter Study.AJNR. American journal of neuroradiology · 2024Article
- Antithrombotic therapy following lower extremity endovascular revascularization: The results of a survey of vascular specialists.JVS-vascular insights · 2024Article
7 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAntiplatelet drug resistance has been associated with thromboembolic complications in patients after coronary stent placement. It has not been well-studied in patients who have neurovascular stent-placement procedures. This study aimed to analyze the relationship between antiplatelet drug resistance and neurovascular stent-placement complications. MATERIALS AND
methodsA prospective data base of all patients treated at our institution was used to identify patients with neurovascular stent-placement procedures. During a 4.5-year period, all patients undergoing neurovascular stent placement were evaluated for aspirin and clopidogrel resistance by using the VerifyNow assay. During an observational phase, all patients received 75 mg of clopidogrel and aspirin (group A). During the intervention phase (group B), patients were given additional clopidogrel on the basis of the clopidogrel resistance assay. We assessed the development of thromboembolic complications within 30 days of the procedure in patients who were resistant-versus-nonresistant to clopidogrel.
resultsOf 96 patients who had neurovascular stent placement, 5.2% were resistant to aspirin and 36.5% were resistant to clopidogrel. Periprocedural thromboembolic complications were seen in 7 patients (7.3%). In a multivariate logistic regression model, clopidogrel resistance, higher diastolic blood pressure, and lack of statin use were significantly associated with periprocedural thromboembolic complication. There was a nonsignificant decrease in thromboembolic complications in patients whose clopidogrel dosage was tailored to the assay.
conclusionsIn our series, clopidogrel resistance was associated with increased periprocedural thromboembolic complications from neurovascular stent-placement procedures. Targeting the clopidogrel dose to platelet inhibition assays may improve clinical outcomes and requires further study.
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