ArticleNeuroImage2013
Comparison of psychophysical, electrophysiological, and fMRI assessment of visual contrast responses in patients with schizophrenia.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on Contrast Sensitivity in Schizophrenia.Schizophrenia bulletin · 2025Pooled it
- Alterations of the occipital lobe in schizophrenia.Neurosciences (Riyadh, Saudi Arabia) · 2015Pooled it
- Impaired Contour Object Perception in Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Differential deficits in pattern- versus flash-visual evoked potentials in schizophrenia: relationship to subcortical visual systems, pulvinar nucleus and cognition.Frontiers in neuroimaging · 2026Article
- Disturbances in Auditory and Visual Perceptual Function in Schizophrenia: Patterns, Causes, and Consequences.Current topics in behavioral neurosciences · 2025Review
- Impaired contour object perception in psychosis.medRxiv : the preprint server for health sciences · 2024Article
- Contrast response function estimation with nonparametric Bayesian active learning.Journal of vision · 2024Article
- Dissociable Neural Mechanisms Underlie the Effects of Attention on Visual Appearance and Response Bias.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response.Psychological medicine · 2023Article
- Perceptual Functioning.Current topics in behavioral neurosciences · 2023Article
- Visual Evoked Potential Abnormalities in Phelan-McDermid Syndrome.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study.Brain sciences · 2022Article
- Steady state visual evoked potentials in schizophrenia: A review.Frontiers in neuroscience · 2022Review
- Cognitive function mediates the relationship between visual contrast sensitivity and functional outcome in schizophrenia.Journal of psychiatric research · 2021Article
- Neural markers of suppression in impaired binocular vision.NeuroImage · 2021Article
- Abberant inverted U-shaped brain pattern and trait-related retinal impairment in schizophrenia patients with combined auditory and visual hallucinations: a pilot study.Brain imaging and behavior · 2021Article
- Irreversible Primary Visual Cortex Impairment in a Mouse Model of High-Risk Schizophrenia.Neuropsychiatric disease and treatment · 2021Article
- Antipsychotic agents deteriorate brain and retinal function in schizophrenia patients with combined auditory and visual hallucinations: A pilot study and secondary follow-up study.Brain and behavior · 2020Article
- Objective Assessment of the Effect of Optical Treatment on Magnocellular and Parvocellular-biased Visual Response in Anisometropic Amblyopia.Investigative ophthalmology & visual science · 2020Article
- Deficits in Auditory and Visual Sensory Discrimination Reflect a Genetic Liability for Psychosis and Predict Disruptions in Global Cognitive Functioning.Frontiers in psychiatry · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Perception has been identified by the NIMH-sponsored Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) group as a useful domain for assessing cognitive deficits in patients with schizophrenia. Specific measures of contrast gain derived from recordings of steady-state visual evoked potentials (ssVEP) have demonstrated neural deficits within the visual pathways of patients with schizophrenia. Psychophysical measures of contrast sensitivity have also shown functional loss in these patients. In the current study, functional magnetic resonance imaging (fMRI) was used in conjunction with ssVEP and contrast sensitivity testing to elucidate the neural underpinnings of these deficits. During fMRI scanning, participants viewed 1) the same low and higher spatial frequency stimuli used in the psychophysical contrast sensitivity task, at both individual detection threshold contrast and at a high contrast; and 2) the same stimuli used in the ssVEP paradigm, which were designed to be biased toward either the magnocellular or parvocellular visual pathway. Patients showed significant impairment in contrast sensitivity at both spatial frequencies in the psychophysical task, but showed reduced occipital activation volume for low, but not higher, spatial frequency at the low and high contrasts tested in the magnet. As expected, patients exhibited selective deficits under the magnocellular-biased ssVEP condition. However, occipital lobe fMRI responses demonstrated the same general pattern for magnocellular- and parvocellular-biased stimuli across groups. These results indicate dissociation between the fMRI measures and the psychophysical/ssVEP measures. These latter measures appear to have greater value for the functional assessment of the contrast deficits explored here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.