ArticlePsychological medicine2013
A genetic perspective on the proposed inclusion of cannabis withdrawal in DSM-5.
Article in Psychological medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Clinical management of cannabis withdrawal.Addiction (Abingdon, England) · 2022Review
- US Epidemiology of Cannabis Use and Associated Problems.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Cannabis and Depression: A Twin Model Approach to Co-morbidity.Behavior genetics · 2017Article
- The cannabis withdrawal syndrome: current insights.Substance abuse and rehabilitation · 2017Review
- Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and addictive phenotypes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Trauma exposure, posttraumatic stress disorder and risk for alcohol, nicotine, and marijuana dependence in Israel.Comprehensive psychiatry · 2014Article
- DSM-5 cannabis use disorder: a phenotypic and genomic perspective.Drug and alcohol dependence · 2014Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundVarious studies support the inclusion of cannabis withdrawal in the diagnosis of cannabis use disorder (CUD) in the upcoming DSM-5. The aims of the current study were to (1) estimate the prevalence of DSM-5 cannabis withdrawal (criterion B), (2) estimate the role of genetic and environmental influences on individual differences in cannabis withdrawal and (3) determine the extent to which genetic and environmental influences on cannabis withdrawal overlap with those on DSM-IV-defined abuse/dependence.
methodThe sample included 2276 lifetime cannabis-using adult Australian twins. Cannabis withdrawal was defined in accordance with criterion B of the proposed DSM-5 revisions. Cannabis abuse/dependence was defined as endorsing one or more DSM-IV criteria of abuse or three or more dependence criteria. The classical twin model was used to estimate the genetic and environmental influences on variation in cannabis withdrawal, along with its covariation with abuse/dependence.
resultsOf all the cannabis users, 11.9% met criteria for cannabis withdrawal. Around 50% of between-individual variation in withdrawal could be attributed to additive genetic variation, and the rest of the variation was mostly due to non-shared environmental influences. Importantly, the genetic influences on cannabis withdrawal almost completely (99%) overlapped with those on abuse/dependence.
conclusionsWe have shown that cannabis withdrawal symptoms exist among cannabis users, and that cannabis withdrawal is moderately heritable. Genetic influences on cannabis withdrawal are the same as those affecting abuse/dependence. These results add to the wealth of literature that recommends the addition of cannabis withdrawal to the diagnosis of DSM-5 CUD.
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