Evidence map›Paper›PMID 23194487›Full record

ArticleAmerican heart journal2012

Cardiovascular effects of 1 year of progressive endurance exercise training in patients with heart failure with preserved ejection fraction.

Naoki Fujimoto, Anand Prasad, Jeffrey L Hastings, Paul S Bhella, Shigeki Shibata, Dean Palmer, Benjamin D Levine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 5 pooled it
32.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 5 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Naoki FujimotoThe University of Texas Southwestern Medical Center at Dallas, USA.
Anand Prasad
Jeffrey L Hastings
Paul S Bhella
Shigeki Shibata
Dean Palmer
Benjamin D Levine
Presbyterian Hospital · USInstitute for Exercise and Environmental Medicine · USThe University of Texas Southwestern Medical Center · US

Funding

Aging Fitness & Failure: Mechanisms of Diastolic DysfunctionR01AG017479 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LEVINE, BENJAMIN D · 2001 to 2016
$7.8M
NIA NIH HHS R01 AG017479
6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is a disease of the elderly with cardiovascular stiffening and reduced exercise capacity. Exercise training appears to improve exercise capacity and cardiovascular function in heart failure with reduced ejection fraction. However, it is unclear whether exercise training could improve cardiovascular stiffness, exercise capacity, and ventricular-arterial coupling in HFpEF.

methodsEleven HFpEF patients and 13 healthy controls underwent invasive measurements with right heart catheterization to define Starling and left ventricular (LV) pressure-volume curves; secondary functional outcomes included Doppler echocardiography, arterial stiffness, cardiopulmonary exercise testing with cardiac output measurement, and ventricular-arterial coupling assessed by the dynamic Starling mechanism. Seven of 11 HFpEF patients (74.9 ± 6 years; 3 men/4 women) completed 1 year of endurance training followed by repeat measurements. Pulmonary capillary wedge pressures and LV end-diastolic volumes were measured at baseline during decreased and increased cardiac filling. LV compliance was assessed by the slope of the pressure-volume curve. Beat-to-beat LV end-diastolic pressure (estimated from pulmonary arterial diastolic pressure) and stroke volume index were obtained, and spectral transfer function analysis was used to assess the dynamic Starling mechanism.

resultsBefore training, HFpEF patients had reduced exercise capacity, distensibility and dynamic Starling mechanism but similar LV compliance and end-diastolic volumes compared to controls albeit with elevated filling pressure and increased wall stress. One year of training had little effect on LV compliance and volumes, arterial stiffness, exercise capacity or ventricular-arterial coupling.

conclusionContrary to our hypothesis, 1 year of endurance training failed to impart favorable effects on cardiovascular stiffness or function in HFpEF.

Indexed as

Exercise TherapyAgedAged, 80 and overCase-Control StudiesEchocardiography, DopplerExercise TestExercise ToleranceFemaleHeart FailureHumansMaleStroke VolumeTreatment OutcomeVascular StiffnessVentricular Function, Left

Identifiers

PMID23194487
PMCPMC3727249
OpenAlexW2095863612

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.