ArticleExperimental & translational stroke medicine2012
A modified double injection model of cisterna magna for the study of delayed cerebral vasospasm following subarachnoid hemorrhage in rats.
Article in Experimental & translational stroke medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Posterior communicating artery vasospasm impairs cerebral pulsatility in an experimental subarachnoid hemorrhage model.Frontiers in neurology · 2025Article
- Development and Validation of a Prechiasmatic Mouse Model of Subarachnoid Hemorrhage to Measure Long-Term Cognitive Deficits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Development and validation of prechiasmatic mouse model of subarachnoid hemorrhage to measure long-term neurobehavioral impairment.Research square · 2024Article
- BuyangHuanwu Decoction attenuates cerebral vasospasm caused by subarachnoid hemorrhage in rats via PI3K/AKT/eNOS axis.Open life sciences · 2022Article
- The ESAS-score: A histological severity grading system of subarachnoid hemorrhage using the modified double hemorrhage model in rats.PloS one · 2020Article
- Effect of thrombin injection on cerebral vascular in rats with subarachnoid hemorrhage.The Journal of international medical research · 2019Article
- Long-Lasting Cerebral Vasospasm, Microthrombosis, Apoptosis and Paravascular Alterations Associated with Neurological Deficits in a Mouse Model of Subarachnoid Hemorrhage.Molecular neurobiology · 2018Article
- A Comparison of Pathophysiology in Humans and Rodent Models of Subarachnoid Hemorrhage.Frontiers in molecular neuroscience · 2018Review
- Alterations in the expression of protease-activated receptor 1 and tumor necrosis factor-α in the basilar artery of rats following a subarachnoid hemorrhage.Experimental and therapeutic medicine · 2016Article
- Ultrasound guided double injection of blood into cisterna magna: a rabbit model for treatment of cerebral vasospasm.Biomedical engineering online · 2016Article
- 4'-O-β-D-glucosyl-5-O-methylvisamminol, an active ingredient of Saposhnikovia divaricata, attenuates high-mobility group box 1 and subarachnoid hemorrhage-induced vasospasm in a rat model.Behavioral and brain functions : BBF · 2015Article
- Experimental subarachnoid hemorrhage: double cisterna magna injection rat model--assessment of delayed pathological effects of cerebral vasospasm.Translational stroke research · 2015Article
- Valproic acid attenuates intercellular adhesion molecule-1 and E-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model.Journal of inflammation (London, England) · 2015Article
- Arctigenin, a Potent Ingredient of Arctium lappa L., Induces Endothelial Nitric Oxide Synthase and Attenuates Subarachnoid Hemorrhage-Induced Vasospasm through PI3K/Akt Pathway in a Rat Model.BioMed research international · 2015Article
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6 authors.
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Abstract
Delayed cerebral vasospasm following subarachnoid hemorrhage (SAH) is a serious medical complication, characterized by constriction of cerebral arteries leading to varying degrees of cerebral ischemia. Numerous clinical and experimental studies have been performed in the last decades; however, the pathophysiologic mechanism of cerebral vasospasm after SAH still remains unclear. Among a variety of experimental SAH models, the double hemorrhage rat model involving direct injection of autologous arterial blood into the cisterna magna has been used most frequently for the study of delayed cerebral vasospasm following SAH in last years. Despite the simplicity of the technique, the second blood injection into the cisterna magna may result in brainstem injury leading to high mortality. Therefore, a modified double hemorrhage model of cisterna magna has been developed in rat recently. We describe here step by step the surgical technique to induce double SAH and compare the degree of vasospasm with other cisterna magna rat models using histological assessment of the diameter and cross-sectional area of the basilar artery.
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