ArticleMolecular oral microbiology2013
Comparative genomic hybridization and transcriptome analysis with a pan-genome microarray reveal distinctions between JP2 and non-JP2 genotypes of Aggregatibacter actinomycetemcomitans.
Article in Molecular oral microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Serotype Distribution ofPathogens (Basel, Switzerland) · 2025Article
- Rapid Griess assay (RGA): a chairside test forJournal of oral microbiology · 2025Article
- Occurrence ofMicroorganisms · 2024Article
- Genomic Islands Shape the Genetic Background of Both JP2 and Non-JP2Pathogens (Basel, Switzerland) · 2022Article
- Discrepancies in Antimicrobial Susceptibility between the JP2 and the Non-JP2 Genotype ofAntibiotics (Basel, Switzerland) · 2022Article
- Herpesvirus-bacteria synergistic interaction in periodontitis.Periodontology 2000 · 2020Review
- Oral and Fecal Microbiome in Molar-Incisor Pattern Periodontitis.Frontiers in cellular and infection microbiology · 2020Article
- Transcriptomic Analysis ofPathogens (Basel, Switzerland) · 2019Article
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- Pathogenicity of the highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans and its geographic dissemination and role in aggressive periodontitis.Journal of oral microbiology · 2014Review
- Bacterial sex in dental plaque.Journal of oral microbiology · 2013Article
- Differential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes.Journal of oral microbiology · 2013Article
- Genomic Stability of Aggregatibacter actinomycetemcomitans during Persistent Oral Infection in Human.PloS one · 2013Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
It was postulated that the highly virulent JP2 genotype of Aggregatibacter actinomycetemcomitans may possess a constellation of distinct virulence determinants not found in non-JP2 genotypes. This study compared the genome content and the transcriptome of the serotype b JP2 genotype and the closely related serotype b non-JP2 genotype of A. actinomycetemcomitans. A custom-designed pan-genomic microarray of A. actinomycetemcomitans was constructed and validated against a panel of 11 sequenced reference strains. The microarray was subsequently used for comparative genomic hybridization of serotype b strains of JP2 (six strains) and non-JP2 (six strains) genotypes, and for transcriptome analysis of strains of JP2 (three strains) and non-JP2 (two strains). Two JP2-specific and two non-JP2-specific genomic islands were identified. In one instance, distinct genomic islands were found to be inserted into the same locus among strains of different genotypes. Transcriptome analysis identified five operons, including the leukotoxin operon, to have at least two genes with an expression ratio of 2 or greater between genotypes. Two of the differentially expressed operons were members of the membrane-bound nitrate reductase system (nap operon) and the Tol-Pal system of gram-negative bacterial species. This study is the first to demonstrate the differences in the full genome content and gene expression between A. actinomycetemcomitans strains of JP2 and non-JP2 genotypes. The information is essential for designing hypothesis-driven experiments to examine the pathogenic mechanisms of A. actinomycetemcomitans.
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