ArticleJournal of biomedicine & biotechnology2012
Sensitive HPV genotyping based on the flow-through hybridization and gene chip.
Article in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- From cervix to multisite: Detection of lower genital tract lesions in a 10-year cross-sectional colposcopy clinic study.PloS one · 2025Article
- The performance of JAM3/PAX1 methylation in the diagnosis of high-grade squamous intraepithelial lesions for women with high-risk HPV infection.BMC cancer · 2024Article
- Epidemiological study of human papillomavirus infection in 105,679 women in Wuhan, China.BMC infectious diseases · 2024Article
- Exploring the potential prompting role of cervical human papilloma virus detection in vulvar lesions: a cross-sectional study in China.Frontiers in oncology · 2024Article
- HighZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion.Scientific reports · 2023Article
- Prevalent distribution and survival outcome of HPV infection in patients with early-stage cervical cancer in Hangzhou, China.BMC infectious diseases · 2022Article
- Association between Prestored Smartphone Monitored Physical Activity and the Risk of HPV Infection and Cervical Cancer.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- The characteristics and risk factors of human papillomavirus infection: an outpatient population-based study in Changsha, Hunan.Scientific reports · 2021Article
- Heat maps present the spatial distribution of human papillomavirus infection in Zhejiang Province, China.Oncology letters · 2021Article
- Analysis of influencing factors of viral load in patients with high-risk human papillomavirus.Virology journal · 2021Article
- Efficient combination of Human Papillomavirus Genotyping for the triage of women with Atypical Squamous Cells of Undetermined Significance in Chinese rural population: A population-based study.Journal of Cancer · 2021Article
- Predictive value of p16Experimental and therapeutic medicine · 2020Article
- The Efficiency of Type-Specific High-Risk Human Papillomavirus Models in the Triage of Women with Atypical Squamous Cells of Undetermined Significance.Cancer management and research · 2020Article
- Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China.Journal of clinical laboratory analysis · 2018Article
- CRISPR-typing PCR (ctPCR), a new Cas9-based DNA detection method.Scientific reports · 2018Article
- Prevalence and Distribution of HPV Genotypes in 1387 Women with Cervical Intraepithelial Neoplasia 2/3 in Shanxi Province, China.Journal of Cancer · 2018Article
- Article
- Association between folate status and cervical intraepithelial neoplasia.European journal of clinical nutrition · 2016Article
- Metabolic Syndrome and Risk of Cervical Human Papillomavirus Incident and Persistent Infection.Medicine · 2016Observational
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent infection of high-risk human papillomavirus (HPV) has been recognized as the direct cause of cervical carcinoma. Therefore, detection and genotyping of HPV are important to cervical-cancer screening. In this study, we have evaluated the efficacy of flow-through hybridization and gene chip (HybriMax) on HPV genotyping through comparison of the results with Hybrid Capture II (HC-II) and in situ hybridization (ISH). 591 women were classified into 6 groups according to their histological diagnoses. The overall accordance rate on 13 types of HPV genotypes between HybriMax and HC-II were 92.5% and 100% in the cancer group. The overall accordance was excellent with the Kappa index (KI) of 0.814. The value of KI in each group was 0.750 (normal cytological diagnosis), 0.781 (chronic cervicitis), 0.80 (condyloma acuminatum), 0.755 (cervical intraepithelial neoplasia (CIN) I), 0.723 (CIN II), and 0.547 (CIN III) (0.75 > KI > 0.4, good; KI ≥ 0.75, excellent). The 10 most common HPV subtype detected by HybriMax were 16, 52/58, 18, 33, 31, 81, 53, 68, and 66 in patients, and 16, 68, 18, 52, 58, 11, 53, 31/39, and 33 in normal controls. In conclusion, HybriMax is an efficient method for HPV genotyping and more suitable for clinical use.
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