ArticleNucleic acids research2013
LUCApedia: a database for the study of ancient life.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Examining sleep signals at the cradle of life: can phylogenomic analysis of the Last Universal Common Ancestor (LUCA) reveal the fundamental role of sleep?Molecular genetics and genomics : MGG · 2026Article
- Protein Architecture Comparisons and the Reconstruction of the Last Universal Common Ancestor (LUCA).Methods in molecular biology (Clifton, N.J.) · 2026Article
- A new LUCApedia database for data-driven research on early evolutionary history.Bioinformatics advances · 2026Article
- Coenzyme-protein interactions since early life.eLife · 2025Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- The Origin(s) of LUCA: Computer Simulation of a New Theory.Life (Basel, Switzerland) · 2025Article
- On the Nature of the Last Common Ancestor: A Story from its Translation Machinery.Journal of molecular evolution · 2024Review
- On Protein Loops, Prior Molecular States and Common Ancestors of Life.Journal of molecular evolution · 2024Review
- The Unfinished Reconstructed Nature of the Last Universal Common Ancestor.Journal of molecular evolution · 2024Review
- A New View of the Last Universal Common Ancestor.Journal of molecular evolution · 2024Article
- Introduction to the Special Issue on Early Evolution and the Last Common Ancestor.Journal of molecular evolution · 2024Article
- Peptides En Route from Prebiotic to Biotic Catalysis.Accounts of chemical research · 2024Article
- Electron transport chains as a window into the earliest stages of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Natural History of DNA-Dependent DNA Polymerases: Multiple Pathways to the Origins of DNA.Viruses · 2023Article
- Serpentinization as the source of energy, electrons, organics, catalysts, nutrients and pH gradients for the origin of LUCA and life.Frontiers in microbiology · 2023Review
- A consensus view of the proteome of the last universal common ancestor.Ecology and evolution · 2022Article
- Scaling laws in enzyme function reveal a new kind of biochemical universality.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cofactors are Remnants of Life's Origin and Early Evolution.Journal of molecular evolution · 2021Article
- The Coevolution of Cellularity and Metabolism Following the Origin of Life.Journal of molecular evolution · 2020Article
- A New Analysis of Archaea-Bacteria Domain Separation: Variable Phylogenetic Distance and the Tempo of Early Evolution.Molecular biology and evolution · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organisms represented by the root of the universal evolutionary tree were most likely complex cells with a sophisticated protein translation system and a DNA genome encoding hundreds of genes. The growth of bioinformatics data from taxonomically diverse organisms has made it possible to infer the likely properties of early life in greater detail. Here we present LUCApedia, (http://eeb.princeton.edu/lucapedia), a unified framework for simultaneously evaluating multiple data sets related to the Last Universal Common Ancestor (LUCA) and its predecessors. This unification is achieved by mapping eleven such data sets onto UniProt, KEGG and BioCyc IDs. LUCApedia may be used to rapidly acquire evidence that a certain gene or set of genes is ancient, to examine the early evolution of metabolic pathways, or to test specific hypotheses related to ancient life by corroborating them against the rest of the database.
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