Trial reportDiabetes care2013
Clinical evaluation of a personalized artificial pancreas.
Trial report in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 119 citations in OpenAlex.
- Artificial Pancreas: Clinical Study in Latin America Without Premeal Insulin Boluses.Journal of diabetes science and technology · 2018Trial
- Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas.Diabetes care · 2016Trial
- Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes: A 24-Hour Randomized Controlled Crossover Study.Journal of diabetes science and technology · 2015Trial
- Adjustment of Open-Loop Settings to Improve Closed-Loop Results in Type 1 Diabetes: A Multicenter Randomized Trial.The Journal of clinical endocrinology and metabolism · 2015Trial
- Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor.Journal of diabetes science and technology · 2015Trial
- Preliminary evaluation of a new semi-closed-loop insulin therapy system over the prandial period in adult patients with type 1 diabetes: the WP6.0 Diabeloop study.Journal of diabetes science and technology · 2014Trial
- Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas.Diabetes care · 2014Trial
- Autonomous and continuous adaptation of a bihormonal bionic pancreas in adults and adolescents with type 1 diabetes.The Journal of clinical endocrinology and metabolism · 2014Trial
- Artificial pancreas using a personalized rule-based controller achieves overnight normoglycemia in patients with type 1 diabetes.Diabetes technology & therapeutics · 2014Trial
- Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience.Journal of diabetes science and technology · 2013Trial
- Artificial Pancreas: The First 20 Years.Journal of diabetes science and technology · 2025Article
- Early Stages of Automated Insulin Delivery.Journal of diabetes science and technology · 2025Review
- Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.Diabetes technology & therapeutics · 2025Review
- Research Gaps, Challenges, and Opportunities in Automated Insulin Delivery Systems.Journal of diabetes science and technology · 2025Review
- Early Stages of Automated Insulin Delivery.Diabetes technology & therapeutics · 2025Review
- Review
- A Deep Learning Framework for Automatic Meal Detection and Estimation in Artificial Pancreas Systems.Sensors (Basel, Switzerland) · 2022Article
- Current Advances of Artificial Pancreas Systems: A Comprehensive Review of the Clinical Evidence.Diabetes & metabolism journal · 2021Review
- One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology.Diabetes technology & therapeutics · 2021Article
- Impact of Accelerating Insulin on an Artificial Pancreas System Without Meal Announcement: An In Silico Examination.Journal of diabetes science and technology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveAn artificial pancreas (AP) that automatically regulates blood glucose would greatly improve the lives of individuals with diabetes. Such a device would prevent hypo- and hyperglycemia along with associated long- and short-term complications as well as ease some of the day-to-day burden of frequent blood glucose measurements and insulin administration. RESEARCH DESIGN AND
methodsWe conducted a pilot clinical trial evaluating an individualized, fully automated AP using commercial devices. Two trials (n = 22, n(subjects) = 17) were conducted using a multiparametric formulation of model predictive control and an insulin-on-board algorithm such that the control algorithm, or "brain," can be embedded on a chip as part of a future mobile device. The protocol evaluated the control algorithm for three main challenges: 1) normalizing glycemia from various initial glucose levels, 2) maintaining euglycemia, and 3) overcoming an unannounced meal of 30 ± 5 g carbohydrates.
resultsInitial glucose values ranged from 84-251 mg/dL. Blood glucose was kept in the near-normal range (80-180 mg/dL) for an average of 70% of the trial time. The low and high blood glucose indices were 0.34 and 5.1, respectively.
conclusionsThese encouraging short-term results reveal the ability of a control algorithm tailored to an individual's glucose characteristics to successfully regulate glycemia, even when faced with unannounced meals or initial hyperglycemia. To our knowledge, this represents the first truly fully automated multiparametric model predictive control algorithm with insulin-on-board that does not rely on user intervention to regulate blood glucose in individuals with type 1 diabetes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.