ArticleDiabetes care2013
Arterial stiffness is associated with cardiovascular, renal, retinal, and autonomic disease in type 1 diabetes.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Association of arterial stiffness and eye disease: a systematic review and meta-analysis.BMJ open ophthalmology · 2025Pooled it
- Effect of lixisenatide on arterial stiffness in people with type 2 diabetes and kidney disease: Results of a randomised controlled trial.Diabetes, obesity & metabolism · 2026Trial
- Dapagliflozin Reduces Ambulatory Arterial Stiffness Index in CKD Patients with and Without Diabetes Independently of Blood Pressure Control: Results from the GLUcose Transport and Renal PROtection in Chronic Kidney Disease (GLUTREPRO) Trial.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Trial
- Bromocriptine Improves Central Aortic Stiffness in Adolescents With Type 1 Diabetes: Arterial Health Results From the BCQR-T1D Study.Hypertension (Dallas, Tex. : 1979) · 2023Trial
- Pulse pressure is not an independent predictor of outcome in type 2 diabetes patients with chronic kidney disease and anemia--the Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT).Journal of human hypertension · 2016Trial
- The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus.Cardiovascular diabetology · 2014 · on this mapTrial
- Topology-preserving, diameter-specific framework for conjunctival vessel segmentation and tortuosity analysis in diabetes.Scientific reports · 2026Article
- Visceral fat rating, but not glycemic variability, is strongly associated with arterial stiffness in non-obese adults with type 1 diabetes.Scientific reports · 2026Article
- The cross-talk between arterial stiffness and microvascular complications in diabetes mellitus: a systematic review of the literature.Journal of diabetes and metabolic disorders · 2025Review
- Metabolomic risk predictors of diabetic foot complications: A longitudinal observational study in type 1 diabetes.Diabetes, obesity & metabolism · 2025Observational
- Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study.Diabetes care · 2025Article
- The associations between functional vitamin K status and all-cause mortality, cardiovascular disease and end-stage kidney disease in persons with type 1 diabetes.Diabetes, obesity & metabolism · 2025Article
- Circulating metabolomic markers in association with overall burden of microvascular complications in type 1 diabetes.BMJ open diabetes research & care · 2024Article
- Reduced methylation correlates with diabetic nephropathy risk in type 1 diabetes.The Journal of clinical investigation · 2023Article
- Time-varying parameters of glycemic control and glycation in relation to arterial stiffness in patients with type 1 diabetes.Cardiovascular diabetology · 2022Article
- Circulating metabolites and molecular lipid species are associated with future cardiovascular morbidity and mortality in type 1 diabetes.Cardiovascular diabetology · 2022Article
- Arterial stiffness in patients with type 1 diabetes and its comparison to cardiovascular risk evaluation tools.Cardiovascular diabetology · 2022Article
- Nitric oxide-dependent micro- and macrovascular dysfunction occurs early in adolescents with type 1 diabetes.American journal of physiology. Endocrinology and metabolism · 2022Article
- Effects of Acute Interval Exercise on Arterial Stiffness and Cardiovascular Autonomic Regulatory Responses: A Narrative Review of Potential Impacts of Aging.Frontiers in cardiovascular medicine · 2022Review
- Arterial Stiffness in Type 1 Diabetes: The Case for the Arterial Wall Itself as a Target Organ.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn patients with type 1 diabetes, we investigated the association between arterial stiffness and diabetes complications. RESEARCH DESIGN AND
methodsThis was a cross-sectional study including 676 Caucasian patients with type 1 diabetes (374 [55%] men, aged 54 ± 13 years [mean ± SD]) and 51 nondiabetic controls (28 [55%] men, aged 47 ± 13 years). Aortic pulse wave velocity (PWV) was measured with SphygmoCor (AtCor Medical, Sydney, Australia) for 635 patients and all 51 controls.
resultsPWVs (mean ± SD) in patients and controls were 10.4 ± 3.4 and 7.6 ± 1.9 m/s, respectively (P < 0.001). After multivariate adjustment, PWV correlated with age, diabetes duration, urinary albumin excretion rate, heart rate, and blood pressure (P < 0.05 for all). ANCOVA was used for comparisons between groups and adjusted for gender, age, estimated glomerular filtration rate, heart rate, HbA(1c), and 24-h mean arterial pressure. PWVs in normoalbuminuric, microalbuminuric, and macroalbuminuric patients were 9.5 ± 3.2, 11.0 ± 3.6, and 11.4 ± 3.0 m/s, respectively (adjusted P < 0.001). PWV in patients with previous cardiovascular disease, versus patients without, was 12.1 ± 3.5 vs. 10.0 ± 3.2 m/s, respectively (adjusted P < 0.001). PWVs in patients with high (≥140/90 mmHg) versus intermediate (130-40/80-89 mmHg) and low (<130/80 mmHg) blood pressure were 11.8 ± 3.6, 10.0 ± 3.0, and 9.8 ± 3.3 m/s, respectively (adjusted P < 0.001). Furthermore, PWV increased with increasing degree of retinopathy: 8.0 ± 2.5 m/s (nil), 10.0 ± 2.8 m/s (simplex), 12.1 ± 3.5 m/s (proliferative), and 12.7 ± 2.4 m/s (blind), respectively (adjusted P < 0.001). Finally, PWV increased with abnormal heart rate variability: 11.5 ± 3.3 m/s vs. 10.1 ± 3.1 m/s (borderline) and 8.1 ± 2.1 m/s (normal) (adjusted P = 0.027).
conclusionsArterial stiffness increased with presence and duration of type 1 diabetes. Furthermore, PWV increased with all the investigated diabetes complications (cardiovascular, renal, retinal, and autonomic disease) independently of other risk factors.
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