ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Tetrahydrobiopterin increases NO-dependent vasodilation in hypercholesterolemic human skin through eNOS-coupling mechanisms.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Four weeks of vitamin D supplementation improves nitric oxide-mediated microvascular function in college-aged African Americans.American journal of physiology. Heart and circulatory physiology · 2020Trial
- Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Trial
- Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction.International journal of cardiology. Heart & vasculature · 2023Article
- Within-limb variation in skin pigmentation does not influence cutaneous vasodilation.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Climate change and the prevention of cardiovascular disease.American journal of preventive cardiology · 2022Review
- Skin pigmentation is negatively associated with circulating vitamin D concentration and cutaneous microvascular endothelial function.American journal of physiology. Heart and circulatory physiology · 2022Article
- The evolution of human skin pigmentation involved the interactions of genetic, environmental, and cultural variables.Pigment cell & melanoma research · 2021Review
- Vascular Health Triad in Humans With Hypertension-Not the Usual Suspects.Frontiers in physiology · 2021Review
- AHA/ACC-defined stage 1 hypertensive adults do not display cutaneous microvascular endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2020Article
- Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow.European journal of applied physiology · 2020Review
- Sunscreen or simulated sweat minimizes the impact of acute ultraviolet radiation on cutaneous microvascular function in healthy humans.Experimental physiology · 2019Article
- Effect of statins on the association between high temperature and all-cause mortality in a socioeconomically disadvantaged population: a cohort study.Scientific reports · 2019Article
- Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation.American journal of physiology. Heart and circulatory physiology · 2018Article
- Edward F. Adolph Distinguished Lecture: Skin-deep insights into vascular aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- The colours of humanity: the evolution of pigmentation in the human lineage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
- Role of folic acid in nitric oxide bioavailability and vascular endothelial function.Nutrition reviews · 2017Review
- Regulation of exercise blood flow: Role of free radicals.Free radical biology & medicine · 2016Review
- Dairy cheese consumption ameliorates single-meal sodium-induced cutaneous microvascular dysfunction by reducing ascorbate-sensitive oxidants in healthy older adults.The British journal of nutrition · 2016Article
- Acute dairy milk ingestion does not improve nitric oxide-dependent vasodilation in the cutaneous microcirculation.The British journal of nutrition · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Localized exogenous R-tetrahydrobiopterin (R-BH(4)) corrects the deficit in local heat-induced vasodilation (VD) in hypercholesterolemic (HC) human skin through one of two plausible mechanisms: by serving as an essential cofactor to stabilizing endothelial nitric oxide (NO) synthase (eNOS) or through generalized antioxidant effects. We used the stereoisomer S-BH(4), which has the same antioxidant properties but does not function as an essential NOS cofactor, to elucidate the mechanism by which R-BH(4) restores cutaneous VD in HC humans. Intradermal microdialysis fibers were placed in 20 normocholesterolemic (NC), 13 midrange cholesterolemic (MC), and 18 HC (LDL: 94 ± 3, 124 ± 3 and 179 ± 6 mg/dl, respectively) men and women to perfuse Ringer (control site) and R-BH(4). In 10 NC, 13 MC, and 9 HC subjects (LDL: 94 ± 3, 124 ± 3, 180 ± 10 mg/dl), S-BH(4) was perfused at a third microdialysis site. Skin blood flow was measured during a standardized local heating protocol to elicit eNOS-dependent VD. After cutaneous vascular conductance (CVC = LDF/MAP) plateaued, NO-dependent VD was quantified by perfusing N(G)-nitro-l-arginine methyl ester (l-NAME). Data were normalized as %CVC(max). Fully expressed VD (NC: 97.9 ± 2.3 vs. MC: 85.4 ± 5.4, HC: 79.9 ± 4.2%CVC(max)) and the NO-dependent portion (NC: 62.1 ± 3 vs. MC: 45.8 ± 3.9, HC: 35.7 ± 2.8%CVC(max)) were reduced in HC (both P < 0.01 vs. NC), but only the fully expressed VD was reduced in MC (P < 0.01 vs. NC). R-BH(4) increased the fully expressed (93.9 ± 3.4%CVC(max); P < 0.01) and NO-dependent VD (52.1 ± 5.1%CVC(max); P < 0.01) in HC but not in NC or MC. S-BH(4) increased full-expressed VD in HC (P < 0.01) but did not affect NO-dependent VD in HC or MC. In contrast S-BH(4) attenuated NO-dependent VD in NC (control: 62.1 ± 3 vs. S-BH(4): 41.6 ± 7%CVC(max); P < 0.001). Exogenous R-BH(4) restores NO-dependent VD in HC human skin predominantly through NOS coupling mechanisms but increases full expression of the local heating response through generalized antioxidant properties.
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