ArticleJournal of the Royal Society, Interface2013
On the role of lateral stabilization during early patterning in the pancreas.
Article in Journal of the Royal Society, Interface, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Structural causes of pattern formation and loss through model-independent bifurcation analysis.Journal of mathematical biology · 2025Article
- Microenvironmental entropy dynamics analysis reveals novel insights into Notch-Delta-Jagged decision-making mechanism.iScience · 2024Article
- Article
- Stochastic fluctuations promote ordered pattern formation of cells in the Notch-Delta signaling pathway.PLoS computational biology · 2022Article
- Notch Signaling in Vascular Endothelial Cells, Angiogenesis, and Tumor Progression: An Update and Prospective.Frontiers in cell and developmental biology · 2021Review
- Adaptive Landscape Shaped by Core Endogenous Network Coordinates Complex Early Progenitor Fate Commitments in Embryonic Pancreas.Scientific reports · 2020Article
- Developmentally-Inspired Biomimetic Culture Models to Produce Functional Islet-Like Cells From Pluripotent Precursors.Frontiers in bioengineering and biotechnology · 2020Review
- Agent-based modeling and bifurcation analysis reveal mechanisms of macrophage polarization and phenotype pattern distribution.Scientific reports · 2019Article
- A multiscale model of epigenetic heterogeneity-driven cell fate decision-making.PLoS computational biology · 2019Article
- Wet-tip versus dry-tip regimes of osmotically driven fluid flow.Scientific reports · 2019Article
- A dynamically diluted alignment model reveals the impact of cell turnover on the plasticity of tissue polarity patterns.Journal of the Royal Society, Interface · 2017Article
- Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype.Journal of the Royal Society, Interface · 2016Article
- Notch Signaling in Pancreatic Development.International journal of molecular sciences · 2015Review
- Development, growth and maintenance of β-cell mass: models are also part of the story.Molecular aspects of medicine · 2015Review
- Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Morpheus: a user-friendly modeling environment for multiscale and multicellular systems biology.Bioinformatics (Oxford, England) · 2014Article
- Transdifferentiation of pancreatic cells by loss of contact-mediated signaling.BMC systems biology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cell fate decision of multi-potent pancreatic progenitor cells between the exocrine and endocrine lineages is regulated by Notch signalling, mediated by cell-cell interactions. However, canonical models of Notch-mediated lateral inhibition cannot explain the scattered spatial distribution of endocrine cells and the cell-type ratio in the developing pancreas. Based on evidence from acinar-to-islet cell transdifferentiation in vitro, we propose that lateral stabilization, i.e. positive feedback between adjacent progenitor cells, acts in parallel with lateral inhibition to regulate pattern formation in the pancreas. A simple mathematical model of transcriptional regulation and cell-cell interaction reveals the existence of multi-stability of spatial patterns whose simultaneous occurrence causes scattering of endocrine cells in the presence of noise. The scattering pattern allows for control of the endocrine-to-exocrine cell-type ratio by modulation of lateral stabilization strength. These theoretical results suggest a previously unrecognized role for lateral stabilization in lineage specification, spatial patterning and cell-type ratio control in organ development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.