ArticleToxicological sciences : an official journal of the Society of Toxicology2013
Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Long-Term Maternal Exposure to Triclosan Provokes Pulmonary Fibrosis in Mouse Offspring.Environment & health (Washington, D.C.) · 2025Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Urinary phenol and paraben concentrations in association with markers of inflammation during pregnancy in Puerto Rico.The Science of the total environment · 2024Article
- Exposure to the anti-microbial chemical triclosan disrupts keratinocyte function and skin integrity in a model of reconstructed human epidermis.Journal of immunotoxicology · 2023Article
- Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma.Current allergy and asthma reports · 2023Review
- Exposure to the immunomodulatory chemical triclosan differentially impacts immune cell populations in the skin of haired (BALB/c) and hairless (SKH1) mice.Toxicology reports · 2022Article
- Effect of triclosan on the pathogenesis of allergic diseases among children.Journal of exposure science & environmental epidemiology · 2022Article
- Dermal Exposure to the Immunomodulatory Antimicrobial Chemical Triclosan Alters the Skin Barrier Integrity and Microbiome in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Potential classification of chemical immunologic response based on gene expression profiles.Journal of immunotoxicology · 2020Article
- Topical Application of the Antimicrobial Agent Triclosan Induces NLRP3 Inflammasome Activation and Mitochondrial Dysfunction.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Physiological responses to cisplatin using a mouse hypersensitivity model.Inhalation toxicology · 2020Article
- Immunotoxicity and allergenic potential induced by topical application of perfluorooctanoic acid (PFOA) in a murine model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Article
- Topical exposure to triclosan inhibits Th1 immune responses and reduces T cells responding to influenza infection in mice.PloS one · 2020Article
- The Impact of Early-Life Exposure to Antimicrobials on Asthma and Eczema Risk in Children.Current environmental health reports · 2019Review
- Contribution of antimicrobials to the development of allergic disease.Current opinion in immunology · 2019Review
- Triclosan-induced alteration of gut microbiome and aggravation of asthmatic airway response in aeroallergen-sensitized mice.Allergy · 2019Article
- Shaping of infant B cell receptor repertoires by environmental factors and infectious disease.Science translational medicine · 2019Observational
- Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study.Journal of exposure science & environmental epidemiology · 2019Article
- Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study.Environment international · 2018Article
- Divergent hypersensitivity responses following topical application of the quaternary ammonium compound, didecyldimethylammonium bromide.Journal of immunotoxicology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
During the last decade, there has been a remarkable and unexplained increase in the prevalence of asthma. These studies were conducted to investigate the role of dermal exposure to triclosan, an endocrine-disrupting compound, on the hypersensitivity response to ovalbumin (OVA) in a murine model of asthma. Triclosan has had widespread use in the general population as an antibacterial and antifungal agent and is commonly found in consumer products such as soaps, deodorants, toothpastes, shaving creams, mouthwashes, and cleaning supplies. For these studies, BALB/c mice were exposed dermally to concentrations of triclosan ranging from 0.75 to 3% (0.375-1.5mg/mouse/day) for 28 consecutive days. Concordantly, mice were ip injected with OVA (0.9 µg) and aluminum hydroxide (0.5mg) on days 1 and 10 and challenged with OVA (125 µg) by pharyngeal aspiration on days 19 and 27. Compared with the animals exposed to OVA alone, increased spleen weights, OVA-specific IgE, interleukin-13 cytokine levels, and numbers of lung eosinophils were demonstrated when mice were coexposed to OVA and triclosan. Statistically significant increases in OVA-specific and nonspecific airway hyperreactivity were observed for all triclosan coexposed groups compared with the vehicle and OVA controls. In these studies, exposure to triclosan alone was not demonstrated to be allergenic; however, coexposure with a known allergen resulted in enhancement of the hypersensitivity response to that allergen, suggesting that triclosan exposure may augment the allergic responses to other environmental allergens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.