ArticleJournal of cardiovascular translational research2013
Murine cytomegalovirus (MCMV) infection upregulates P38 MAP kinase in aortas of Apo E KO mice: a molecular mechanism for MCMV-induced acceleration of atherosclerosis.
Article in Journal of cardiovascular translational research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human cytomegalovirus infection and coronary heart disease: a systematic review.Virology journal · 2018Pooled it
- Atherosclerosis by Virus Infection-A Short Review.Biomedicines · 2022Review
- Don't Go Breaking My Heart: MCMV as a Model for HCMV-Associated Cardiovascular Diseases.Pathogens (Basel, Switzerland) · 2021Review
- Immunophenotyping of Rhesus CMV-Specific CD8 T-Cell Populations.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2021Article
- Overview of Human Cytomegalovirus Pathogenesis.Methods in molecular biology (Clifton, N.J.) · 2021Review
- A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease-Do Mice Lie?International journal of molecular sciences · 2020Review
- Screening and validation of differentially expressed microRNAs and target genes in hypertensive mice induced by cytomegalovirus infection.Bioscience reports · 2020Article
- Novel Strategies to Combat CMV-Related Cardiovascular Disease.Pathogens & immunity · 2020Review
- Article
- Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway.Journal of cardiovascular translational research · 2015Article
- Infection and Atherosclerosis Development.Archives of medical research · 2015Review
- Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.The FEBS journal · 2015Review
- Impact of hepatitis C seropositivity on the risk of coronary heart disease events.The American journal of cardiology · 2014Article
- Competitive virus and host RNAs: the interplay of a hidden virus and host interaction.Protein & cell · 2014Review
- The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms.Cardiovascular diabetology · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Multiple studies suggest an association between cytomegalovirus (CMV) infection and atherogenesis; however, the molecular mechanisms by which viral infection might exacerbate atherosclerosis are not well understood. Aortas of MCMV-infected and uninfected Apo E knockout (KO) mice were analyzed for atherosclerotic lesion development and differential gene expression. Lesions in the infected mice were larger and showed more advanced disease compared to the uninfected mice. Sixty percent of the genes in the MAPK pathway were upregulated in the infected mice. p38 and ERK 1/2 MAPK genes were 5.6- and 2.0-fold higher, respectively, in aortas of infected vs. uninfected mice. Levels of VCAM-1, ICAM-1, and MCP-1 were ~2.0-2.6-fold higher in aortas of infected vs. uninfected mice. Inhibition of p38 with SB203580 resulted in lower levels of pro-atherogenic molecules and MCMV viral load in aortas of infected mice. MCMV-induced upregulation of p38 may drive the virus-induced acceleration of atherogenesis observed in our model.
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Registered trials
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