ArticlePurinergic signalling2013
The mechanism of electrically stimulated adenosine release varies by brain region.
Article in Purinergic signalling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Energy Homeostasis Disruption in Neurological Disorders: Mitochondrial Dysfunction, High-Energy Phosphate Transfer, and Extracellular ATP-Dependent Purinergic Dysregulation.International journal of molecular sciences · 2026Review
- Carbon nanospikes have improved sensitivity and antifouling properties for adenosine, hydrogen peroxide, and histamine.Analytical and bioanalytical chemistry · 2023Article
- Extracellular ATP/adenosine dynamics in the brain and its role in health and disease.Frontiers in cell and developmental biology · 2023Review
- Spontaneous Adenosine and Dopamine Cotransmission in the Caudate-Putamen Is Regulated by Adenosine Receptors.ACS chemical neuroscience · 2021Article
- The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.Frontiers in neuroscience · 2021Review
- AACS chemical neuroscience · 2020Article
- Complex sex and estrous cycle differences in spontaneous transient adenosine.Journal of neurochemistry · 2020Article
- Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems.Reviews in analytical chemistry · 2020Article
- Continuous monitoring of adenosine and its metabolites using microdialysis coupled to microchip electrophoresis with amperometric detection.Analytical methods : advancing methods and applications · 2018Article
- Regional Variations of Spontaneous, Transient Adenosine Release in Brain Slices.ACS chemical neuroscience · 2018Article
- Selective and Mechanically Robust Sensors for Electrochemical Measurements of Real-Time Hydrogen Peroxide Dynamics in Vivo.Analytical chemistry · 2018Article
- Very low concentrations of ethanol suppress excitatory synaptic transmission in rat visual cortex.The European journal of neuroscience · 2017Article
- Transient Adenosine Release Is Modulated by NMDA and GABAACS chemical neuroscience · 2017Article
- Adenosine Shifts Plasticity Regimes between Associative and Homeostatic by Modulating Heterosynaptic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Real time adenosine fluctuations detected with fast-scan cyclic voltammetry in the rat striatum and motor cortex.Journal of neuroscience methods · 2015Article
- Clearance of rapid adenosine release is regulated by nucleoside transporters and metabolism.Pharmacology research & perspectives · 2015Article
- Toward sophisticated basal ganglia neuromodulation: Review on basal ganglia deep brain stimulation.Neuroscience and biobehavioral reviews · 2015Review
- Fast-scan Cyclic Voltammetry for the Characterization of Rapid Adenosine Release.Computational and structural biotechnology journal · 2015Review
- Electrochemical Analysis of Neurotransmitters.Annual review of analytical chemistry (Palo Alto, Calif.) · 2015Review
- Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors.Journal of neurochemistry · 2015Article
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Authors and funding
2 authors.
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Abstract
Adenosine plays an important role in neuromodulation and neuroprotection. Recent identification of transient changes in adenosine concentration suggests adenosine may have a rapid modulatory role; however, the extent of these changes throughout the brain is not well understood. In this report, transient changes in adenosine evoked by one second, 60 Hz electrical stimulation trains were compared in the caudate-putamen, nucleus accumbens, hippocampus, and cortex. The concentration of evoked adenosine varies between brain regions, but there is less variation in the duration of signaling. The highest concentration of adenosine was evoked in the dorsal caudate-putamen (0.34 ± 0.08 μM), while the lowest concentration was in the secondary motor cortex (0.06 ± 0.02 μM). In all brain regions, adenosine release was activity-dependent. In the nucleus accumbens, hippocampus, and prefrontal cortex, this release was partly due to extracellular ATP breakdown. However, in the caudate-putamen, release was not due to ATP metabolism but was ionotropic glutamate receptor-dependent. The results demonstrate that transient, activity-dependent adenosine can be evoked in many brain regions but that the mechanism of formation and release varies by region.
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Registered trials
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