ArticleBiomaterials2013
Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 258 citations in OpenAlex.
- From flow to form: structuring and patterning hydrogels using microfluidic approaches.Lab on a chip · 2026Review
- Integrating microchannels and flows into 3D printable granular hydrogel matrices.Lab on a chip · 2026Article
- Vibration-Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis.Advanced healthcare materials · 2026Article
- State-of-the-Art Organ-on-Chip Models and Designs for Medical Applications: A Systematic Review.Biomimetics (Basel, Switzerland) · 2025Review
- Cancer-on-a-chip for precision cancer medicine.Lab on a chip · 2025Review
- Vascular architecture-on-chip: engineering complex blood vessels for reproducing physiological and heterogeneous hemodynamics and endothelial function.Lab on a chip · 2025Article
- Advances and challenges in human 3D solid tumor models.Advanced functional materials · 2025Article
- Models for Studying Ductal Carcinoma In Situ Progression.Advances in experimental medicine and biology · 2025Review
- Shaping the Neurovascular Unit Exploiting Human Brain Organoids.Molecular neurobiology · 2024Review
- Tissue-Engineered Microvessels: A Review of Current Engineering Strategies and Applications.Advanced healthcare materials · 2024Review
- The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models.ACS biomaterials science & engineering · 2024Review
- Vascularized organoid-on-a-chip: design, imaging, and analysis.Angiogenesis · 2024Review
- Cardiovascular human organ-on-a-chip platform for disease modeling, drug development, and personalized therapy.Journal of biomedical materials research. Part A · 2024Review
- Self-assembled and perfusable microvasculature-on-chip for modeling leukocyte trafficking.Lab on a chip · 2024Article
- Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Article
- Development of a perfusable, hierarchical microvasculature-on-a-chip model.Lab on a chip · 2023Article
- Luminal Surface Plasma Treatment of Closed Cylindrical Microchannels: A Tool toward the Creation of On-Chip Vascular Endothelium.ACS biomaterials science & engineering · 2023Article
- Modeling angiogenesis in the human brain in a tissue-engineered post-capillary venule.Angiogenesis · 2023Article
- Key aspects for conception and construction of co-culture models of tumor-stroma interactions.Frontiers in bioengineering and biotechnology · 2023Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The study of angiogenesis is important to understanding a variety of human pathologies including cancer, cardiovascular and inflammatory diseases. In vivo angiogenesis assays can be costly and time-consuming, limiting their application in high-throughput studies. While traditional in vitro assays may overcome these limitations, they lack the ability to accurately recapitulate the main elements of the tissue microenvironment found in vivo, thereby limiting our ability to draw physiologically relevant biological conclusions. To bridge the gap between in vivo and in vitro angiogenesis assays, several microfluidic methods have been developed to generate in vitro assays that incorporate blood vessel models with physiologically relevant three-dimensional (3D) lumen structures. However, these models have not seen widespread adoption, which can be partially attributed to the difficulty in fabricating these structures. Here, we present a simple, accessible method that takes advantage of basic fluidic principles to create 3D lumens with circular cross-sectional geometries through ECM hydrogels that are lined with endothelial monolayers to mimic the structure of blood vessels in vitro. This technique can be used to pattern endothelial cell-lined lumens in different microchannel geometries, enabling increased flexibility for a variety of studies. We demonstrate the implementation and application of this technique to the study of angiogenesis in a physiologically relevant in vitro setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.