ArticleThe Journal of investigative dermatology2013
Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44.
Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- The efficacy of adipose-derived stem cells in burn injuries: a systematic review.Cellular & molecular biology letters · 2024Pooled it
- Setipiprant for Androgenetic Alopecia in Males: Results from a Randomized, Double-Blind, Placebo-Controlled Phase 2a Trial.Clinical, cosmetic and investigational dermatology · 2021Trial
- Prostaglandins: Key players in immunomodulation of the nervous system.Neural regeneration research · 2026Article
- PTGDS is a potential marker for lung adenocarcinoma identified in a pancancer analysis.Scientific reports · 2026Article
- Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia.Clinical reviews in allergy & immunology · 2025Review
- TGFβ-mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound-induced skin fibrosis.Cell proliferation · 2025Article
- Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics.International journal of molecular sciences · 2024Article
- Multiomics-empowered Deep Phenotyping of Ulcerative Colitis Identifies Biomarker Signatures Reporting Functional Remission States.Journal of Crohn's & colitis · 2023Article
- Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing.Cold Spring Harbor perspectives in biology · 2023Review
- Article
- Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration.Cold Spring Harbor perspectives in biology · 2023Review
- The physiological and pharmacological roles of prostaglandins in hair growth.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022Review
- Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Thymic stromal lymphopoietin controls hair growth.Stem cell reports · 2022Article
- Controlled Release of the α-Tocopherol-Derived Metabolite α-13'-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing.Nanomaterials (Basel, Switzerland) · 2021Article
- Bacteria induce skin regeneration via IL-1β signaling.Cell host & microbe · 2021Article
- Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin DFrontiers in physiology · 2021Review
- Eicosanoids in Skin Wound Healing.International journal of molecular sciences · 2020Review
- Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.Nature communications · 2020Article
- Mechanisms of ivermectin-induced wound healing.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Prostaglandins (PGs) are key inflammatory mediators involved in wound healing and regulating hair growth; however, their role in skin regeneration after injury is unknown. Using wound-induced hair follicle neogenesis (WIHN) as a marker of skin regeneration, we hypothesized that PGD2 decreases follicle neogenesis. PGE2 and PGD2 were elevated early and late, respectively, during wound healing. The levels of WIHN, lipocalin-type prostaglandin D2 synthase (Ptgds), and its product PGD2 each varied significantly among background strains of mice after wounding, and all correlated such that the highest Ptgds and PGD2 levels were associated with the lowest amount of regeneration. In addition, an alternatively spliced transcript variant of Ptgds missing exon 3 correlated with high regeneration in mice. Exogenous application of PGD2 decreased WIHN in wild-type mice, and PGD2 receptor Gpr44-null mice showed increased WIHN compared with strain-matched control mice. Furthermore, Gpr44-null mice were resistant to PGD2-induced inhibition of follicle neogenesis. In all, these findings demonstrate that PGD2 inhibits hair follicle regeneration through the Gpr44 receptor and imply that inhibition of PGD2 production or Gpr44 signaling will promote skin regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.