ArticleThe Pediatric infectious disease journal2013
Prospective detection of respiratory pathogens in symptomatic children with cancer.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Human metapneumovirus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: A systematic review.Cancer letters · 2016Pooled it
- Parainfluenza virus infections in hematopoietic cell transplant recipients and hematologic malignancy patients: A systematic review.Cancer letters · 2016Pooled it
- Review
- Frequency and Clinical Outcomes of Respiratory Infections in Children with Cancer Presenting with Febrile Illness.South Asian journal of cancer · 2025Article
- Etiology and Factors Affecting Severe Complications and Mortality of Febrile Neutropenia in Children with Acute LeukemiaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023Article
- Approach to hematopoietic cell transplant candidates with respiratory viral detection.Frontiers in pediatrics · 2023Review
- Lung microbiome in children with hematological malignancies and lower respiratory tract infections.Frontiers in oncology · 2022Article
- Review
- Viral Respiratory Infections in Hematological Patients.Infectious diseases and therapy · 2020Review
- Pulmonary Infectious Complications in Children with Hematologic Malignancies and Chemotherapy-Induced Neutropenia.Diseases (Basel, Switzerland) · 2020Review
- HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients.Pathogens (Basel, Switzerland) · 2020Review
- The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2020Article
- Possible role of highly activated mucosal NK cells against viral respiratory infections in children undergoing haematopoietic stem cell transplantation.Scientific reports · 2019Article
- Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients?Microorganisms · 2019Review
- Long-term morbidity of respiratory viral infections during chemotherapy in children with leukaemia.Pediatric pulmonology · 2019Article
- Characteristics and Outcomes of Coronavirus Infection in Children: The Role of Viral Factors and an Immunocompromised State.Journal of the Pediatric Infectious Diseases Society · 2019Article
- Respiratory Viral Infections in Children and Adolescents with Hematological Malignancies.Mediterranean journal of hematology and infectious diseases · 2019Article
- Burden of human metapneumovirus infections in patients with cancer: Risk factors and outcomes.Cancer · 2017Article
- Human rhinovirus C infections in pediatric hematology and oncology patients.Pediatric transplantation · 2015Article
- The role of multiplex PCR in respiratory tract infections in children.Deutsches Arzteblatt international · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
background: The data on human rhinovirus, coronavirus, bocavirus, metapneumovirus, Chlamydophila pneumoniae, Mycoplasma pneumoniae and Bordetella pertussis infections in children with cancer is limited.
methods: We sought to determine prospectively the prevalence of respiratory pathogens in these children, using multiplexed-polymerase chain reaction.
results: We enrolled 253 children with upper or lower respiratory tract infection (LRTI) during a 1-year period. A respiratory virus was detected in 193 (76%) patients; 156 (81%) patients had upper respiratory tract infection. Human rhinovirus was the most common virus detected in 97 (62%) and 24 (65%) patients with upper respiratory tract infection and LRTI, respectively. Leukemia or lymphoma was the most common underlying diagnosis in 95 (49%) patients followed by solid tumor 47 (24%), posthematopoietic stem cell transplant 28 (15%) and brain tumor in 23 (12%) patients. By multiple logistic regression analysis, human bocavirus was the most commonly detected respiratory virus in patients with LRTI (P = 0.008; odds ratio, 4.52; 95% confidence interval: 1.48-13.79). Coinfection with >1 virus was present in 47 (24%) patients, and did not increase the risk for LRTI. Two (0.7%) patients succumbed to LRTI from parainfluenza virus-3 and respiratory syncytial virus/human rhinovirus infection, respectively. C. pneumoniae and M. pneumoniae were detected in 4 and 3 patients, respectively.
conclusions: Human rhinovirus was the most common virus detected in children with cancer and posthematopoietic stem cell transplant hospitalized with an acute respiratory illness, and was not associated with increased morbidity. Prospective studies with viral load determination and asymptomatic controls are needed to study the association of these emerging respiratory viruses with LRTI in children with cancer and posthematopoietic stem cell transplant.
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