ArticleBMC complementary and alternative medicine2012
Antimicrobial activities of endophytic fungi isolated from Ophiopogon japonicus (Liliaceae).
Article in BMC complementary and alternative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 105 citations in OpenAlex.
- Network Pharmacology and Integrated Experimental Evidence Demonstrate That Ophiopogonin D Suppresses Hepatocellular Carcinoma Progression via the UCK2-SLC7A11 Axis.Food science & nutrition · 2026Article
- Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1-mediated macrophage polarization via the PI3K/Akt pathway.Animal models and experimental medicine · 2026Article
- Antifungal and enzymatic activities of endophytic fungi associated withPlant signaling & behavior · 2025Article
- Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya.International journal of microbiology · 2024Article
- Determination of biological activities of nanoparticles containing silver and copper in water disinfection with/without ultrasound technique.Journal of environmental health science & engineering · 2023Article
- Article
- Review
- Characterization and purification of esterase from Cellulomonas fimi DB19 isolated from Zanthoxylum armatum with its possible role in diesel biodegradation.Archives of microbiology · 2022Article
- Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance.Archives of microbiology · 2021Review
- Alkaloids Used as Medicines: Structural Phytochemistry Meets Biodiversity-An Update and Forward Look.Molecules (Basel, Switzerland) · 2021Review
- Ophiopogonin D attenuates PM2.5-induced inflammation via suppressing the AMPK/NF-κB pathway in mouse pulmonary epithelial cells.Experimental and therapeutic medicine · 2020Article
- Antimicrobial activity of endophytic fungi from the medicinal plants Mammea americana (Calophyllaceae) and Moringa oleifera (Moringaceae)Biomedica : revista del Instituto Nacional de Salud · 2020Article
- The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells.International journal of environmental research and public health · 2019Article
- The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies.Antibiotics (Basel, Switzerland) · 2019Review
- Systematic Review of Herbal Tea (a Traditional Chinese Treatment Method) in the Therapy of Chronic Simple Pharyngitis and Preliminary Exploration about Its Medication Rules.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- The structures and biological functions of polysaccharides from traditional Chinese herbs.Progress in molecular biology and translational science · 2019Review
- Isolation and characterization of plumbagin (5- hydroxyl- 2- methylnaptalene-1,4-dione) producing endophytic fungiBiotechnology reports (Amsterdam, Netherlands) · 2018Article
- Diversity and Characterization of Endophytic Fungi Isolated From the Tropical Mangrove Species,Frontiers in microbiology · 2018Article
- Article
- Methods forJournal of pharmaceutical analysis · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDrug resistance in bacteria has become a global concern and the search for new antibacterial agents is urgent and ongoing. Endophytes provide an abundant reservoir of bioactive metabolites for medicinal exploitation, and an increasing number of novel compounds are being isolated from endophytic fungi. Ophiopogon japonicus, containing compounds with antibacterial activity, is a traditional Chinese medicinal plant used for eliminating phlegm, relieving coughs, latent heat in the lungs, and alleviating diabetes mellitus. We investigated the antimicrobial activities of 30 strains of O. japonicus.
methodsFungal endophytes were isolated from roots and stems of O. japonicus collected from Chongqing City, southwestern China. Mycelial extracts (MC) and fermentation broth (FB) were tested for antimicrobial activity using peptide deformylase (PDF) inhibition fluorescence assays and MTT cell proliferation assays.
resultsA total of 30 endophytic strains were isolated from O. japonicus; 22 from roots and eight from stems. 53.33% of the mycelial extracts (MC) and 33.33% of the fermentation broths (FB) displayed potent inhibition of PDF. 80% of MC and 33.33% of FB significantly inhibited Staphylococcus aureus. 70% of MC and 36.67% of FB showed strong activities against Cryptococcus neoformans. None showed influence on Escherichia coli.
conclusionThe secondary metabolites of endophytic fungi from O. japonicus are potential antimicrobial agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.